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Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles (NANPs)
Title
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles (NANPs)
Author
Panigaj, Martin, Skelly, Elizabeth, Beasock, Damian, Marriott, Ian
Date Created
2023
Subjects--Topical
Immunology, Immune response--Regulation
Description
The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Title
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Author
Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
Date Created
2023
Subjects--Topical
Nucleic acids, Chemistry
Description
The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...
The recognition of and reactions to nucleic acid nanoparticles by human immune cells
Title
The recognition of and reactions to nucleic acid nanoparticles by human immune cells
Author
Afonin, Kirill A., Bila, Dominika, Panigaj, Martin
Date Created
2021
Subjects--Topical
Nucleic acids, Chemistry
Description
The relatively straightforward methods of designing and assembling various functional nucleic acids into nanoparticles offer advantages for applications in diverse diagnostic and therapeutic approaches. However, due to the novelty of this approach...
Functionally-interdependent shape-switching nanoparticles with controllable properties
Title
Functionally-interdependent shape-switching nanoparticles with controllable properties
Author
Halman, Justin, Khisamutdinov, Emil F., Afonin, Kirill A., Satterwhite, Emily, Roark, Brandon, Chandler, Morgan, Ivanina, Anna, Viard, Mathias, Bindewald, Eckart, Kasprzak, Wojciech K., Panigaj, Martin, Bui, My N., Lu, Jacob S., Miller, Johann, Shapiro, Bruce A., Dobrovolskaia, Marina A.
Subjects--Topical
Nucleic acids, Nanotechnology
Description
We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...