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ELUCIDATING THE EFFECTS OF MUTATION AND EVOLUTIONARY DIVERGENCE UPON PROTEIN STRUCTURE QUANTITATIVE STABILITY/FLEXIBILITY RELATIONSHIPS
Title
ELUCIDATING THE EFFECTS OF MUTATION AND EVOLUTIONARY DIVERGENCE UPON PROTEIN STRUCTURE QUANTITATIVE STABILITY/FLEXIBILITY RELATIONSHIPS
Author
Verma, Deeptak
Date Created
2012
Subjects--Topical
Bioinformatics
Description
The importance of flexibility and stability on protein function has been recognized for over five decades. A protein must be flexible enough to mediate a reaction pathway, yet rigid enough to achieve high fidelity in molecular recognition. To unde...
DE NOVO PREDICTION OF CIS-REGULATORY MODULES IN EUKARYOTIC ORGANISMS
Title
DE NOVO PREDICTION OF CIS-REGULATORY MODULES IN EUKARYOTIC ORGANISMS
Author
Niu, Meng
Date Created
2014
Subjects--Topical
Bioinformatics
Description
Gene regulation networks (GRNs) are the bases for virtually all biological processes. To gain a global understanding of GRNs encoded in a genome, we first need to identify in all the cis-regulatory elements (CREs) recognized by transcription facto...
Evolution and dynamics of transcriptional regulation in bacteria
Title
Evolution and dynamics of transcriptional regulation in bacteria
Author
Li, Shan
Date Created
2013
Subjects--Topical
Computer science, Statistics, Bioinformatics
Description
Although transcription is one of the most important biological functions of cells, our understanding of its regulation is still limited. In this dissertation, we have studied the transcriptional regulation in prokaryotes in three aspects. First, w...
A STRUCTURAL AND FUNCTIONAL ANALYSIS OF NEMATOSTELLA VECTENSIS MAJOR INTRINSIC PROTEINS
Title
A STRUCTURAL AND FUNCTIONAL ANALYSIS OF NEMATOSTELLA VECTENSIS MAJOR INTRINSIC PROTEINS
Author
Taylor, Jonathon
Date Created
2020
Subjects--Topical
Biology, Cytology, Evolutionary developmental biology
Description
There is currently a major gap in understanding the physiological processes of tissue grade animals from early diverging phyla, particularly within the context of the molecular mechanisms in response to osmotic variation. A key protein family esse...
The evolution of flavonoid pathway in legumes
Title
The evolution of flavonoid pathway in legumes
Author
Safari, Sajedeh
Date Created
2016
Subjects--Topical
Bioinformatics
Description
Considering the ever growing world population as well as climate change, it has become essential to improve crops in order to reach higher yields, more tolerance to pests and droughts, and better adaptation to different environments. The advanceme...
The in-vivo Evolution of Burkholderia multivorans in a Cystic Fibrosis patient
Title
The in-vivo Evolution of Burkholderia multivorans in a Cystic Fibrosis patient
Author
Harrison, Sarah
Date Created
2021
Subjects--Topical
Biology, Microbiology, Bioinformatics
Description
ABSTRACT Burkholderia multivorans is an opportunistic pathogen that poses a health risk to patients with cystic fibrosis (CF). The use of broad-range antibiotics to combat chronic bacterial lung infections has led to the evolution of antibiotic-re...