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Variations within class-a beta-lactamase physiochemical properties reflect evolutionary and environmental patterns, but not antibiotic specificity
Title
Variations within class-a beta-lactamase physiochemical properties reflect evolutionary and environmental patterns, but not antibiotic specificity
Author
Jacobs, Donald J., Verma, Deeptak, Livesay, Dennis R.
Date Created
2013
Subjects--Topical
Biology, Bacteria
Description
The bacterial enzyme beta-lactamase hydrolyzes the beta-lactam ring of penicillin and chemically related antibiotics, rendering them ineffective. Due to rampant antibiotic overuse, the enzyme is evolving new resistance activities at an alarming ra...
Changes in Lysozyme flexibility upon mutation are frequent, large and long-ranged
Title
Changes in Lysozyme flexibility upon mutation are frequent, large and long-ranged
Author
Jacobs, Donald J., Verma, Deeptak, Livesay, Dennis R.
Date Created
2012
Subjects--Topical
Bioinformatics, Statistics
Description
We investigate changes in human c-type lysozyme flexibility upon mutation via a Distance Constraint Model, which gives a statistical mechanical treatment of network rigidity. Specifically, two dynamical metrics are tracked. Changes in flexibility ...