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DO DYNAMIC ALLOSTERIC EFFECTS OCCUR IN IGG4 ANTIBODIES?
Title
DO DYNAMIC ALLOSTERIC EFFECTS OCCUR IN IGG4 ANTIBODIES?
Author
Baker, Lonnie
Date Created
2020
Subjects--Topical
Bioinformatics, Biophysics
Description
Antibodies are large, multi-chain proteins which play a critical roll in the func-tioning of vertebrate immune systems. Immune effector cells which are responsiblefor the destruction of foreign antigens do not randomly target molecules but rely on...
Functional dynamics of substrate recognition in tem beta-lactamase
Title
Functional dynamics of substrate recognition in tem beta-lactamase
Author
Jacobs, Donald J., Avery, Chris, Baker, Lonnie
Date Created
2022
Subjects--Topical
Machine learning, Molecular dynamics
Description
The beta-lactamase enzyme provides effective resistance to beta-lactam antibiotics due to substrate recognition controlled by point mutations. Recently, extended-spectrum and inhibitor-resistant mutants have become a global health problem. Here, t...