Search results
- Title
- The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
- Author
- Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
- Subjects--Topical
- Immunology, Nucleic acids, Nanoparticles
- Description
- Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
- Title
- Functionally-interdependent shape-switching nanoparticles with controllable properties
- Author
- Halman, Justin, Khisamutdinov, Emil F., Afonin, Kirill A., Satterwhite, Emily, Roark, Brandon, Chandler, Morgan, Ivanina, Anna, Viard, Mathias, Bindewald, Eckart, Kasprzak, Wojciech K., Panigaj, Martin, Bui, My N., Lu, Jacob S., Miller, Johann, Shapiro, Bruce A., Dobrovolskaia, Marina A.
- Subjects--Topical
- Nucleic acids, Nanotechnology
- Description
- We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
- Title
- Toll-like receptor-mediated recognition of nucleic acid nanoparticles (NANPs) in human primary blood cells
- Author
- Afonin, Kirill A., Truong, Nguyen, Halman, Justin
- Date Created
- 2019
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Infusion reactions (IRs) create a translational hurdle for many novel therapeutics, including those utilizing nanotechnology. Nucleic acid nanoparticles (NANPs) are a novel class of therapeutics prepared by rational design of relatively short olig...
- Title
- Broccoli fluorets : split aptamers as a user-friendly fluorescent toolkit for dynamic RNA nanotechnology
- Author
- Afonin, Kirill A., Chandler, Morgan, Halman, Justin
- Date Created
- 2018
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- RNA aptamers selected to bind fluorophores and activate their fluorescence offer a simple and modular way to visualize native RNAs in cells. Split aptamers which are inactive until the halves are brought within close proximity can become useful fo...
- Title
- The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
- Author
- Afonin, Kirill A., Marriott, Ian, Halman, Justin
- Date Created
- 2020
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
- Title
- Artificial immune cell, AI-cell, a new tool to predict interferon production by peripheral blood monocytes in response to nucleic acid nanoparticles
- Author
- Afonin, Kirill A., Chandler, Morgan, Halman, Justin
- Date Created
- 2022
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human immune system, can offer innovative therapeutic strategies to overcome the limitations of traditional nucleic acid therapies. Each set of NANPs is unique in th...
- Title
- Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
- Author
- Afonin, Kirill A., Marriott, Ian, Halman, Justin
- Date Created
- 2020
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...
- Title
- Functionally-interdependent shape-switching nanoparticles with controllable properties
- Author
- Afonin, Kirill A., Halman, Justin, Chandler, Morgan
- Date Created
- 2017
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
- Title
- Editorial for the special issue on nucleic acid architectures for therapeutics, diagnostics, devices and materials
- Author
- Afonin, Kirill A., Halman, Justin
- Date Created
- 2019
- Subjects--Topical
- Nucleic acids, Chemistry
- Title
- Break to build : isothermal assembly of nucleic acid nanoparticles (NANPs) via enzymatic degradation
- Author
- Beasock, Damian, Ha, Anh, Halman, Justin, Afonin, Kirill A.
- Date Created
- 2023
- Subjects--Topical
- Genetics, Peptides
- Description
- The intrinsic properties of RNA and DNA biopolymers emphasized by engineered nucleic acid nanoparticles (NANPs) offer accelerated development of next-generation therapies. The rational design of NANPs facilitates programmable architectures intende...