Search results | J. Murrey Atkins Library

Title: Changes in Lysozyme flexibility upon mutation are frequent, large and long-ranged
Author: Jacobs, Donald J., Verma, Deeptak, Livesay, Dennis R.
Date Created: 2012
Subjects--Topical: Bioinformatics, Statistics
Description: We investigate changes in human c-type lysozyme flexibility upon mutation via a Distance Constraint Model, which gives a statistical mechanical treatment of network rigidity. Specifically, two dynamical metrics are tracked. Changes in flexibility ...

Title: Rigidity emerges during antibody evolution in three distinct antibody systems: evidence from QSFR analysis of fab fragments
Author: Jacobs, Donald J., Li, Tong, Livesay, Dennis R.
Date Created: 2015
Subjects--Topical: Immunoglobulins, Biology
Description: The effects of somatic mutations that transform polyspecific germline (GL) antibodies to affinity mature (AM) antibodies with monospecificity are compared among three GL-AM Fab pairs. In particular, changes in conformational flexibility are assess...

Title: Variations within class-a beta-lactamase physiochemical properties reflect evolutionary and environmental patterns, but not antibiotic specificity
Author: Jacobs, Donald J., Verma, Deeptak, Livesay, Dennis R.
Date Created: 2013
Subjects--Topical: Biology, Bacteria
Description: The bacterial enzyme beta-lactamase hydrolyzes the beta-lactam ring of penicillin and chemically related antibiotics, rendering them ineffective. Due to rampant antibiotic overuse, the enzyme is evolving new resistance activities at an alarming ra...