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A new strategy to infer circularity applied to four new complete frog mitogenomes
Title
A new strategy to infer circularity applied to four new complete frog mitogenomes
Author
Machado, Denis Jacob, Janies, Daniel, Brouwer, Cory, Grant, Taran
Date Created
2018
Subjects--Topical
Genomics, Amphibians, Bioinformatics
Description
We applied a novel strategy to infer sequence circularity and complete assembly of four mitochondrial genomes (mitogenomes) of the frog families Bufonidae (Melanophryniscus moreirae), Dendrobatidae (Hyloxalus subpunctatus and Phyllobates terribili...
ANCESTRAL COMPLEXITY AND LINEAGE SPECIFIC EXPANSIONS OF THE ANIMAL BZIP INTERACTOME
Title
ANCESTRAL COMPLEXITY AND LINEAGE SPECIFIC EXPANSIONS OF THE ANIMAL BZIP INTERACTOME
Author
Kane, Eric
Date Created
2017
Subjects--Topical
Bioinformatics, Evolutionary developmental biology
Description
Protein-protein interactions are central to the regulation and function of transcription factors in time- and cell-specific regulation of the genome. Increases in interactome complexity may serve as a mechanistic driver for evolutionary novelty. T...
Analysis of pollen-specific alternative splicing in Arabidopsis thaliana via semi-quantitative PCR
Title
Analysis of pollen-specific alternative splicing in Arabidopsis thaliana via semi-quantitative PCR
Author
Loraine, Ann, Estrada, April, Freese, Nowlan H., Blakley, Ivory
Date Created
2015
Subjects--Topical
Bioinformatics, Pollen, Nucleic acids
Description
Alternative splicing enables a single gene to produce multiple mRNA isoforms by varying splice site selection. In animals, alternative splicing of mRNA isoforms between cell types is widespread and supports cellular differentiation. In plants, at ...
Arabidopsis bioinformatics resources : the current state, challenges, and priorities for the future
Title
Arabidopsis bioinformatics resources : the current state, challenges, and priorities for the future
Author
Loraine, Ann, Doherty, Colleen, Friesner, Joanna, Gregory, Brian
Date Created
2019
Subjects--Topical
Bioinformatics, Arabidopsis thaliana
Description
Effective research, education, and outreach efforts by the Arabidopsis thaliana community, as well as other scientific communities that depend on Arabidopsis resources, depend vitally on easily available and publicly-shared resources. These resour...
Changes in Lysozyme flexibility upon mutation are frequent, large and long-ranged
Title
Changes in Lysozyme flexibility upon mutation are frequent, large and long-ranged
Author
Jacobs, Donald J., Verma, Deeptak, Livesay, Dennis R.
Date Created
2012
Subjects--Topical
Bioinformatics, Statistics
Description
We investigate changes in human c-type lysozyme flexibility upon mutation via a Distance Constraint Model, which gives a statistical mechanical treatment of network rigidity. Specifically, two dynamical metrics are tracked. Changes in flexibility ...
DO DYNAMIC ALLOSTERIC EFFECTS OCCUR IN IGG4 ANTIBODIES?
Title
DO DYNAMIC ALLOSTERIC EFFECTS OCCUR IN IGG4 ANTIBODIES?
Author
Baker, Lonnie
Date Created
2020
Subjects--Topical
Bioinformatics, Biophysics
Description
Antibodies are large, multi-chain proteins which play a critical roll in the func-tioning of vertebrate immune systems. Immune effector cells which are responsiblefor the destruction of foreign antigens do not randomly target molecules but rely on...
Genome-scale cluster analysis of replicated microarrays using shrinkage correlation coefficient
Title
Genome-scale cluster analysis of replicated microarrays using shrinkage correlation coefficient
Author
Loraine, Ann, Yao, Jianchao, Chang, Chunqi, Roux, Stanley J.
Date Created
2008
Subjects--Topical
Genomics, Bioinformatics
Description
Background: Currently, clustering with some form of correlation coefficient as the gene similarity metric has become a popular method for profiling genomic data. The Pearson correlation coefficient and the standard deviation (SD)-weighted correlat...
THERMODYNAMIC AND MECHANICAL EFFECTS OF DISULFIDE BONDS IN CXCL7 CHEMOKINE
Title
THERMODYNAMIC AND MECHANICAL EFFECTS OF DISULFIDE BONDS IN CXCL7 CHEMOKINE
Author
Singer, Christopher
Date Created
2015
Subjects--Topical
Physics, Bioinformatics, Biophysics
Description
Chemokines are a family of signaling proteins mainly responsible for the chemotaxis of leukocytes, where their biological activity is modulated by their oligomerization state. Here, the dynamics and thermodynamic stability are characterized in mon...
The in-vivo Evolution of Burkholderia multivorans in a Cystic Fibrosis patient
Title
The in-vivo Evolution of Burkholderia multivorans in a Cystic Fibrosis patient
Author
Harrison, Sarah
Date Created
2021
Subjects--Topical
Biology, Microbiology, Bioinformatics
Description
ABSTRACT Burkholderia multivorans is an opportunistic pathogen that poses a health risk to patients with cystic fibrosis (CF). The use of broad-range antibiotics to combat chronic bacterial lung infections has led to the evolution of antibiotic-re...