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Repression of MUC1 promotes expansion and suppresive function of myeloid-derived suppressor cells in pancreatic and breast cancer murine models
Title
Repression of MUC1 promotes expansion and suppresive function of myeloid-derived suppressor cells in pancreatic and breast cancer murine models
Author
Mukherjee, Pinku, Bose, Mukulika, Sanders, J. Alexa, De, Chandrav
Date Created
2021
Subjects--Topical
Pancreas--Cancer, Pancreas--Cancer--Genetic aspects
Description
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that are responsible for immunosuppression in tumor microenvironment. Here we report the impact of mucin 1 (MUC1), a transmembrane glycoprotein, on proliferation and functional ac...