Search results | J. Murrey Atkins Library

Title: Commonality of functional annotation : a method for prioritization of candidate genes from genome-wide linkage studies
Author: Loraine, Ann, Shriner, Daniel, Baye, Tesfaye M., Padilla, Miguel A.
Date Created: 2008
Subjects--Topical: Gene expression, Alzheimer's disease
Description: Linkage studies of complex traits frequently yield multiple linkage regions covering hundreds of genes. Testing each candidate gene from every region is prohibitively expensive and computational methods that simplify this process would benefit gen...

Title: Conformational entropy of an ideal cross-linking polymer chain
Author: Jacobs, Donald J., Vorov, Oleg, Livesay, Dennis R.
Date Created: 2008
Subjects--Topical: Proteins, Entropy
Description: We present a novel analytical method to calculate conformational entropy of ideal cross-linking polymers from the configuration integral by employing a Mayer series expansion. Mayer-functions describing chemical bonds within the chain and for cros...

Title: Genome-scale cluster analysis of replicated microarrays using shrinkage correlation coefficient
Author: Loraine, Ann, Yao, Jianchao, Chang, Chunqi, Roux, Stanley J.
Date Created: 2008
Subjects--Topical: Genomics, Bioinformatics
Description: Background: Currently, clustering with some form of correlation coefficient as the gene similarity metric has become a popular method for profiling genomic data. The Pearson correlation coefficient and the standard deviation (SD)-weighted correlat...

Title: Hydrogen bond networks determine emergent mechanical and thermodynamic properties across a protein family
Author: Jacobs, Donald J., Livesay, Dennis R.
Date Created: 2008
Subjects--Topical: Bacteria, Proteins
Description: Background: Gram-negative bacteria use periplasmic-binding proteins (bPBP) to transport nutrients through the periplasm. Despite immense diversity within the recognized substrates, all members of the family share a common fold that includes two do...