Search results
-
-
Title
-
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles (NANPs)
-
Author
-
Panigaj, Martin, Skelly, Elizabeth, Beasock, Damian, Marriott, Ian
-
Date Created
-
2023
-
Subjects--Topical
-
Immunology, Immune response--Regulation
-
Description
-
The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...
-
-
Title
-
ROLE OF THE NOVEL DNA SENSORS cGAS, IFI16, AND ZBP1, DURING VIRAL INFECTIONS IN GLIA
-
Author
-
Jeffries, Austin
-
Date Created
-
2020
-
Subjects--Topical
-
Immunology, Virology, Neurosciences
-
Description
-
Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
-
-
Title
-
THE ROLE OF MUC1 IN REGULATION AND PROGRESSION OF CANCER
-
Author
-
Sahraeimanouchehrabadi, Mahnaz
-
Date Created
-
2011
-
Subjects--Topical
-
Immunology, Biology, Oncology
-
Description
-
MUC1 is a heavily glycosylated transmembrane glycoprotein which is overexpressed and aberrantly glycosylated in most human carcinomas. MUC1 contains a large tandem repeat, a short transmembrane, and a small cytoplasmic tail. Both tandem repeat and...
-
-
Title
-
Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
-
Author
-
Suptela, Alexander
-
Date Created
-
2023
-
Subjects--Topical
-
Immunology, Molecular biology, Neurosciences
-
Description
-
Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses (DDRs) is a critical step in maintaining genomic int...
-
-
Title
-
Inflammation, NLRP3 Inflammasomes, Macrophages and Breast Cancer Progression
-
Author
-
Holtzman , Katherine
-
Date Created
-
2021
-
Subjects--Topical
-
Biology, Immunology, Oncology
-
Description
-
One in 8 women will be diagnosed with breast cancer in their lifetime and while breast cancer mortality has declined since the 1980s, it remains the 2nd leading cause of cancer-related deaths among women. Standard of care is determined by anatomic...
-
-
Title
-
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
-
Author
-
Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
-
Subjects--Topical
-
Immunology, Nucleic acids, Nanoparticles
-
Description
-
Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...