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INVESTIGATING THE ROLE OF NEWLY DESCRIBED CYTOSOLIC PATTERN RECOGNITION RECEPTORS IN PROTECTIVE HOST RESPONSES TO NEUROTROPIC VIRUSES
Title
INVESTIGATING THE ROLE OF NEWLY DESCRIBED CYTOSOLIC PATTERN RECOGNITION RECEPTORS IN PROTECTIVE HOST RESPONSES TO NEUROTROPIC VIRUSES
Author
Crill, Emma
Date Created
2014
Subjects--Topical
Immunology, Virology
Description
The importance of the effector functions performed by glial cells, the resident cells of the CNS possessing immune functions, in abrogating potentially fatal neurotropic viral infections have only recently begun to gain appreciation. These effecto...
Newly described cytosolic pattern recognition receptors mediate inflammatory glial responses to neurotropic viruses
Title
Newly described cytosolic pattern recognition receptors mediate inflammatory glial responses to neurotropic viruses
Author
Furr, Samantha
Date Created
2012
Subjects--Topical
Immunology, Biology
Description
The rapid onset of potentially lethal neuroinflammation is a defining feature of viral encephalitis. Glial cells are ideally positioned to respond to invading pathogens of the central nervous system (CNS) and produce key inflammatory mediators fol...
Inflammation, NLRP3 Inflammasomes, Macrophages and Breast Cancer Progression
Title
Inflammation, NLRP3 Inflammasomes, Macrophages and Breast Cancer Progression
Author
Holtzman , Katherine
Date Created
2021
Subjects--Topical
Biology, Immunology, Oncology
Description
One in 8 women will be diagnosed with breast cancer in their lifetime and while breast cancer mortality has declined since the 1980s, it remains the 2nd leading cause of cancer-related deaths among women. Standard of care is determined by anatomic...
Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
Title
Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
Author
Huff, Laura
Date Created
2020
Subjects--Topical
Immunology, Biology, Pathology
Description
A large portion of patients who survive sepsis, a life-threatening hyperinflammatory response to infection resulting in organ dysfunction, experience a higher risk of mortality than non-septic patients. Innate immune cells of sepsis survivors exhi...
ROLE OF THE NOVEL DNA SENSORS cGAS, IFI16, AND ZBP1, DURING VIRAL INFECTIONS IN GLIA
Title
ROLE OF THE NOVEL DNA SENSORS cGAS, IFI16, AND ZBP1, DURING VIRAL INFECTIONS IN GLIA
Author
Jeffries, Austin
Date Created
2020
Subjects--Topical
Immunology, Virology, Neurosciences
Description
Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
Study of the Intracellular Protein Tau and its Relationship with Kunjin Virus and Neurodegenerative Diseases
Title
Study of the Intracellular Protein Tau and its Relationship with Kunjin Virus and Neurodegenerative Diseases
Author
Lotz, Sarah
Date Created
2022
Subjects--Topical
Neurosciences, Immunology, Virology
Description
Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive loss of nervous system function. Neuroinflammation is increasingly recogni...
THE ROLE OF MUC1 IN REGULATION AND PROGRESSION OF CANCER
Title
THE ROLE OF MUC1 IN REGULATION AND PROGRESSION OF CANCER
Author
Sahraeimanouchehrabadi, Mahnaz
Date Created
2011
Subjects--Topical
Immunology, Biology, Oncology
Description
MUC1 is a heavily glycosylated transmembrane glycoprotein which is overexpressed and aberrantly glycosylated in most human carcinomas. MUC1 contains a large tandem repeat, a short transmembrane, and a small cytoplasmic tail. Both tandem repeat and...
Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
Title
Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
Author
Suptela, Alexander
Date Created
2023
Subjects--Topical
Immunology, Molecular biology, Neurosciences
Description
Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses (DDRs) is a critical step in maintaining genomic int...
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Title
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author
Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
Subjects--Topical
Immunology, Nucleic acids, Nanoparticles
Description
Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles (NANPs)
Title
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles (NANPs)
Author
Panigaj, Martin, Skelly, Elizabeth, Beasock, Damian, Marriott, Ian
Date Created
2023
Subjects--Topical
Immunology, Immune response--Regulation
Description
The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...