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Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
Title
Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
Author
Huff, Laura
Date Created
2020
Subjects--Topical
Immunology, Biology, Pathology
Description
A large portion of patients who survive sepsis, a life-threatening hyperinflammatory response to infection resulting in organ dysfunction, experience a higher risk of mortality than non-septic patients. Innate immune cells of sepsis survivors exhi...
Study of the Intracellular Protein Tau and its Relationship with Kunjin Virus and Neurodegenerative Diseases
Title
Study of the Intracellular Protein Tau and its Relationship with Kunjin Virus and Neurodegenerative Diseases
Author
Lotz, Sarah
Date Created
2022
Subjects--Topical
Neurosciences, Immunology, Virology
Description
Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive loss of nervous system function. Neuroinflammation is increasingly recogni...
INVESTIGATING THE ROLE OF NEWLY DESCRIBED CYTOSOLIC PATTERN RECOGNITION RECEPTORS IN PROTECTIVE HOST RESPONSES TO NEUROTROPIC VIRUSES
Title
INVESTIGATING THE ROLE OF NEWLY DESCRIBED CYTOSOLIC PATTERN RECOGNITION RECEPTORS IN PROTECTIVE HOST RESPONSES TO NEUROTROPIC VIRUSES
Author
Crill, Emma
Date Created
2014
Subjects--Topical
Immunology, Virology
Description
The importance of the effector functions performed by glial cells, the resident cells of the CNS possessing immune functions, in abrogating potentially fatal neurotropic viral infections have only recently begun to gain appreciation. These effecto...
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Title
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author
Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
Subjects--Topical
Immunology, Nucleic acids, Nanoparticles
Description
Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles (NANPs)
Title
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles (NANPs)
Author
Panigaj, Martin, Skelly, Elizabeth, Beasock, Damian, Marriott, Ian
Date Created
2023
Subjects--Topical
Immunology, Immune response--Regulation
Description
The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...