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DNA-templated fluorescent silver nanoclusters inhibit bacterial growth while being non-toxic to mammalian cells
Title
DNA-templated fluorescent silver nanoclusters inhibit bacterial growth while being non-toxic to mammalian cells
Author
Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
Date Created
2021
Subjects--Topical
Nucleic acids, Chemistry
Description
Silver has a long history of antibacterial effectiveness. The combination of atomically precise metal nanoclusters with the field of nucleic acid nanotechnology has given rise to DNA-templated silver nanoclusters (DNA-AgNCs) which can be engineere...
Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
Title
Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
Author
Fessler, Adam
Date Created
2021
Subjects--Topical
Chemistry, Biology
Description
The growing interest in RNA biology, along with an expansion in computational capabilities, throughput, and sensitivity has provided researchers new tools to probe RNA. RNA selective 2′-hydroxy acylation analyzed by primer extension (SHAPE) utiliz...
Induction of cytokines by nucleic acid nanoparticles (NANPs) depends on the type of delivery carrier
Title
Induction of cytokines by nucleic acid nanoparticles (NANPs) depends on the type of delivery carrier
Author
Afonin, Kirill A., Chandler, Morgan, Avila, Yelixza I.
Date Created
2021
Subjects--Topical
Nucleic acids, Chemistry
Description
Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these ...
Synthesis of Asymmetric Thiazolo[5,4-d] Thiazole Derivatives for Molecular Sensing Applications
Title
Synthesis of Asymmetric Thiazolo[5,4-d] Thiazole Derivatives for Molecular Sensing Applications
Author
Meadows, Jared
Date Created
2021
Subjects--Topical
Chemistry, Biochemistry, Materials science
Description
This thesis outlines the synthesis and characterization of new asymmetrically substituted thiazolo[5,4-d]thiazole (TTz) compounds. This class of compounds contains a central bicyclic heteroaromatic system that is electron-deficient, and when subst...
Synthesis, photophysical characterization, and application of asymmetric thiazolothiazoles as molecular sensors
Title
Synthesis, photophysical characterization, and application of asymmetric thiazolothiazoles as molecular sensors
Author
Sayresmith, Nickolas
Date Created
2021
Subjects--Topical
Nanoscience, Chemistry
Description
Small molecule fluorophores are critical for fluorescence spectroscopy, and enable the measurement of a wide array of biological processes and dynamics. For many biological sensing applications, the overall efficacy of the fluorophore is closely c...
The recognition of and reactions to nucleic acid nanoparticles by human immune cells
Title
The recognition of and reactions to nucleic acid nanoparticles by human immune cells
Author
Afonin, Kirill A., Bila, Dominika, Panigaj, Martin
Date Created
2021
Subjects--Topical
Nucleic acids, Chemistry
Description
The relatively straightforward methods of designing and assembling various functional nucleic acids into nanoparticles offer advantages for applications in diverse diagnostic and therapeutic approaches. However, due to the novelty of this approach...