Search results | J. Murrey Atkins Library

Title: Characterization of cationic bolaamphiphile vesicles for sirna delivery into tumors and brain
Author: Afonin, Kirill A., Kim, Taejin, Gupta, Kshitij
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Small interfering RNAs (siRNAs) are potential therapeutic substances due to their gene silencing capability as exemplified by the recent approval by the US Food and Drug Administration (FDA) of the first siRNA therapeutic agent (patisiran). Howeve...

Title: Crystalline Silicon Interfaces with Adhesive Polymer Semiconducting Glue and Thiazolothiazole Redox Active Organic Small Molecules
Author: Cohen, Daniel
Date Created: 2020
Subjects--Topical: Materials science, Chemistry, Chemistry, Organic
Description: Crystalline silicon is an extremely versatile semiconductor material used for electronics and photovoltaic devices. An organic conductive glue based on a blend of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) and d-sorbitol ...

Title: Development of a Surface Enhanced Raman Spectroscopy-based Assay to Detect Malaria Biomarkers in Blood
Author: Hamm, Logan
Date Created: 2020
Subjects--Topical: Chemistry
Description: Malaria is an infectious disease that affects many lives around the world and eradication efforts are focused on controlling the disease transmission; which requires early diagnosis of the infection before the onset of symptoms, i.e. at the asympt...

Title: Development of nanoparticle-based approaches for the treatment and imaging of pancreatic cancer
Author: Tarannum, Mubin
Date Created: 2020
Subjects--Topical: Nanoscience, Chemistry
Description: Pancreatic ductal adenocarcinoma (PDAC) is a type of exocrine pancreatic cancer which accounts for over 90% of cases. PDAC is the fourth-leading cause of cancer-related mortality in the United States with a 5-year survival rate of 9% with little t...

Title: Exosome mediated delivery of functional nucleic acid nanoparticles (NANPs)
Author: Afonin, Kirill A., Ke, Weina
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: RNAi-based technologies have shown biomedical potential; however, safe and efficient delivery of RNA remains a barrier for their broader clinical applications. Nucleic acid nanoparticles (NANPs) programmed to self-assemble and organize multiple th...

Title: Influence of Functional Groups on the Photodynamic Therapy and Internalization of Porphyrin Modified Polyhedral Oligomeric Silsesquioxane (POSS) Molecules in Mammalian Cells
Author: Johnston, Alexis
Date Created: 2020
Subjects--Topical: Chemistry, Chemistry, Inorganic, Chemistry, Organic
Description: Polyhedral Oligomeric Silsesquioxane (POSS) molecules are highly ordered organic- inorganic hybrid materials with a cage like core of alternating silicon and oxygen atoms surrounded by eight pedant organic residues. These compounds are well-define...

Title: Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Author: Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...

Title: SYNTHESIS OF PORPHYRIN-BASED POLYHEDRAL OLIGOMERIC SILSESQUIOXANE MOLECULES FOR IMPROVED PHOTODYNAMIC THERAPY OF CANCER CELLS
Author: Siano, Paolo
Date Created: 2020
Subjects--Topical: Chemistry
Description: Polyhedral Oligomeric Silsesquioxane (POSS) materials are a class of nanostructured compounds based on Si-O linkages forming a cage with a silicon atom at each vertex, where substituents are bound tetrahedrally determining the physical and chemica...

Title: Synthesis and Electrochemical Characterization of [3]Radialene-based Catholytes for Aqueous Organic Redox Flow Batteries
Author: Turner, Nicholas
Date Created: 2020
Subjects--Topical: Chemistry
Description: The unsubstituted [n]radialenes are a unique class of alicyclic hydrocarbons with radiating alkenes. These compounds are typically difficult to handle and polymerize rapidly. A number of stable radialene derivatives that exhibit reversible electro...

Title: The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author: Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...