Search results
- Title
- Artificial immune cell, AI-cell, a new tool to predict interferon production by peripheral blood monocytes in response to nucleic acid nanoparticles
- Author
- Afonin, Kirill A., Chandler, Morgan, Halman, Justin
- Date Created
- 2022
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human immune system, can offer innovative therapeutic strategies to overcome the limitations of traditional nucleic acid therapies. Each set of NANPs is unique in th...
- Title
- Biomotors, viral assembly, and rna nanobiotechnology: current achievements and future directions
- Author
- Afonin, Kirill A., Rolband, Lewis
- Date Created
- 2022
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent adv...
- Title
- Broccoli fluorets : split aptamers as a user-friendly fluorescent toolkit for dynamic RNA nanotechnology
- Author
- Afonin, Kirill A., Chandler, Morgan, Halman, Justin
- Date Created
- 2018
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- RNA aptamers selected to bind fluorophores and activate their fluorescence offer a simple and modular way to visualize native RNAs in cells. Split aptamers which are inactive until the halves are brought within close proximity can become useful fo...
- Title
- Change in lipofectamine carrier as a tool to fine-tune immunostimulation of nucleic acid nanoparticles
- Author
- Afonin, Kirill A., Newton, Hannah S., Xu, Jie
- Date Created
- 2023
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Nucleic acid nanoparticles (NANPs) require a carrier to allow for their intracellular delivery to immune cells. Cytokine production, specifically type I and III interferons, allows for reliable monitoring of the carrier effect on NANP immunostimul...
- Title
- Characterization of cationic bolaamphiphile vesicles for sirna delivery into tumors and brain
- Author
- Afonin, Kirill A., Kim, Taejin, Gupta, Kshitij
- Date Created
- 2020
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Small interfering RNAs (siRNAs) are potential therapeutic substances due to their gene silencing capability as exemplified by the recent approval by the US Food and Drug Administration (FDA) of the first siRNA therapeutic agent (patisiran). Howeve...
- Title
- Crystalline Silicon Interfaces with Adhesive Polymer Semiconducting Glue and Thiazolothiazole Redox Active Organic Small Molecules
- Author
- Cohen, Daniel
- Date Created
- 2020
- Subjects--Topical
- Materials science, Chemistry, Chemistry, Organic
- Description
- Crystalline silicon is an extremely versatile semiconductor material used for electronics and photovoltaic devices. An organic conductive glue based on a blend of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) and d-sorbitol ...
- Title
- DNA-templated fluorescent silver nanoclusters inhibit bacterial growth while being non-toxic to mammalian cells
- Author
- Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
- Date Created
- 2021
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Silver has a long history of antibacterial effectiveness. The combination of atomically precise metal nanoclusters with the field of nucleic acid nanotechnology has given rise to DNA-templated silver nanoclusters (DNA-AgNCs) which can be engineere...
- Title
- Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
- Author
- Fessler, Adam
- Date Created
- 2021
- Subjects--Topical
- Chemistry, Biology
- Description
- The growing interest in RNA biology, along with an expansion in computational capabilities, throughput, and sensitivity has provided researchers new tools to probe RNA. RNA selective 2′-hydroxy acylation analyzed by primer extension (SHAPE) utiliz...
- Title
- Editorial for the special issue on nucleic acid architectures for therapeutics, diagnostics, devices and materials
- Author
- Afonin, Kirill A., Halman, Justin
- Date Created
- 2019
- Subjects--Topical
- Nucleic acids, Chemistry
- Title
- Effects of Weathering on Performance of Intumescent Coatings for Structure Fire Protection in the Wildland-Urban Interface
- Author
- Bahrani, Babak
- Date Created
- 2015
- Subjects--Topical
- Chemistry, Polymers, Materials science, Wood
- Description
- The objective of this study was to investigate the effects of weathering on the performance of intumescent fire-retardant coatings on wooden products. The weathering effects included primary (solar irradiation, moisture, and temperature) and secon...
- Title
- Exosome mediated delivery of functional nucleic acid nanoparticles (NANPs)
- Author
- Afonin, Kirill A., Ke, Weina
- Date Created
- 2020
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- RNAi-based technologies have shown biomedical potential; however, safe and efficient delivery of RNA remains a barrier for their broader clinical applications. Nucleic acid nanoparticles (NANPs) programmed to self-assemble and organize multiple th...
- Title
- Expanding structural space for immunomodulatory nucleic acid nanoparticles (NANPs) via spatial arrangement of their therapeutic moieties
- Author
- Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
- Date Created
- 2022
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Different therapeutic nucleic acids (TNAs) can be unified in a single structure by their elongation with short oligonucleotides designed to self-assemble into nucleic acid nanoparticles (NANPs). With this approach, therapeutic cocktails with preci...
- Title
- Exploring the photophysics and photocatalytic properties of platinum and palladium nanoparticles
- Author
- Major, Kevin
- Date Created
- 2012
- Subjects--Topical
- Nanoscience, Chemistry, Chemistry, Physical and theoretical
- Description
- Platinum and Palladium nanoparticles are important nanoscale materials for a variety of materials science and industrial applications. The presented research covers a broad spectrum of these unique nanoparticles, from their synthesis and character...
- Title
- First step towards larger DNA-based assemblies of fluorescent silver nanoclusters: template design and detailed characterization of optical properties
- Author
- Afonin, Kirill A., Shevchenko, Oleg
- Date Created
- 2019
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Besides being a passive carrier of genetic information, DNA can also serve as an architecture template for the synthesis of novel fluorescent nanomaterials that are arranged in a highly organized network of functional entities such as fluorescent ...
- Title
- Functionally-interdependent shape-switching nanoparticles with controllable properties
- Author
- Afonin, Kirill A., Halman, Justin, Chandler, Morgan
- Date Created
- 2017
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
- Title
- Hexacoordinate Silicon Complexes as Cathodic Colorants
- Author
- Peloquin, Derek
- Date Created
- 2016
- Subjects--Topical
- Nanoscience, Chemistry, Chemistry, Inorganic
- Description
- Electrochemical and spectroelectrochemical characterization of hexacoordinate polypyridine silicon complexes show that they are fitting candidates for electrochromic applications. Tris(bipyridine)silicon(IV), [Si(bpy)3]+4, is colorless in acetonit...
- Title
- Induction of cytokines by nucleic acid nanoparticles (NANPs) depends on the type of delivery carrier
- Author
- Afonin, Kirill A., Chandler, Morgan, Avila, Yelixza I.
- Date Created
- 2021
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these ...
- Title
- LOADED AND ELABORATED POLYESTER NANOMATERIALS FOR THE TREATMENT AND DIAGNOSIS OF DISEASE
- Author
- Fowler, Anthony
- Date Created
- 2017
- Subjects--Topical
- Chemistry, Nanotechnology
- Description
- Cancer is not one disease but many. In fact, cancer is a collection of more than 100 different diseases. Cancer is the second leading cause of death in the United States with an estimated 1.7 million new cases expected in 2017 and approximately 60...
- Title
- PENETRATION RESISTANCE OF 4340 STEEL/POLYUREA LAMINATE
- Author
- Pajjuri, Vishnu Vardhan Kumar
- Date Created
- 2017
- Subjects--Topical
- Mechanical engineering, Military art and science, Chemistry, Polymers
- Description
- Enhancement of the penetration resistance of materials used in the defense industry is of great interest since such improvements can save human life and can reduce the loss of resources caused by high velocity projectiles penetrating through the w...
- Title
- Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
- Author
- Afonin, Kirill A., Marriott, Ian, Halman, Justin
- Date Created
- 2020
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...