Search results | J. Murrey Atkins Library

Title: Venomix : a simple bioinformatic pipeline for identifying and characterizing toxin gene candidates from transcriptomic data
Author: Janies, Daniel, Reitzel, Adam M., Macrander, Jason
Date Created: 2018
Subjects--Topical: Genomics, Biology
Description: The advent of next-generation sequencing has resulted in transcriptome-based approaches to investigate functionally significant biological components in a variety of non-model organism. This has resulted in the area of venomics: a rapidly growing ...

Title: Variations within class-a beta-lactamase physiochemical properties reflect evolutionary and environmental patterns, but not antibiotic specificity
Author: Jacobs, Donald J., Verma, Deeptak, Livesay, Dennis R.
Date Created: 2013
Subjects--Topical: Biology, Bacteria
Description: The bacterial enzyme beta-lactamase hydrolyzes the beta-lactam ring of penicillin and chemically related antibiotics, rendering them ineffective. Due to rampant antibiotic overuse, the enzyme is evolving new resistance activities at an alarming ra...

Title: Variation in Patterns of Allocare In Captive Hamadryas Baboons (Papio hamadryas): The Potential Effects of Environment and Kinship in the Development of Novel Behavior
Author: Carter, Amanda
Date Created: 2016
Subjects--Topical: Biology, Physical anthropology, Zoology
Description: The goal of the this research was to examine the social dynamics among extended matrilines of Hamadryas baboons (Papio hamadryas) housed at the North Carolina Zoo (NCZ) in Asheboro, North Carolina, including the putative existence of allocare, def...

Title: Using Nematostella vectensis to study the interactions between genome, epigenome, and bacteria in a changing environment
Author: Reitzel, Adam M., Fraune, Sebastian, Foret, Sylvain
Date Created: 2016
Subjects--Topical: Gene expression, Biology
Description: The phenotype of an animal cannot be explained entirely by its genes. It is now clear that factors other than the genome contribute to the ecology and evolution of animals. Two fundamentally important factors are the associated microbiota and epig...

Title: Updated phylogeny of chikungunya virus suggests lineage-specific RNA architecture
Author: Janies, Daniel
Date Created: 2019
Subjects--Topical: Communicable diseases, Biology
Description: Chikungunya virus (CHIKV), a mosquito-borne alphavirus of the family Togaviridae, has recently emerged in the Americas from lineages from two continents: Asia and Africa. Historically, CHIKV circulated as at least four lineages worldwide with both...

Title: Understanding and overcoming limitations of vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
Author: Hastie, Eric
Date Created: 2014
Subjects--Topical: Virology, Biology
Description: Vesicular stomatitis virus (VSV) is a prototypic nonsegmented negative-strand RNA virus. Lack of preexisting immunity against VSV, inherent oncotropism, and genetic malleability make VSV a widely used platform for vaccine, oncolytic, and gene ther...

Title: Understanding The Role of Pancreatic Ductal Adenocarcinoma Chemoresistance and Intertumoral Heterogeneity on Vesicular Stomatitis Virus-based Oncolytic Therapy
Author: Goad, Dakota
Date Created: 2023
Subjects--Topical: Biology, Virology, Biomedical engineering
Description: Viruses are obligate intracellular parasites that are now being increasingly harnessed as therapeutics for human diseases. Investigating different cellular factors and processes that affect viral infection allows us to improve the efficacy of viru...

Title: Understanding Salt Adaptation in Sand Beans (Strophostyles helvola)
Author: Zuelsdorf, Christine
Date Created: 2018
Subjects--Topical: Biology
Description: Soil salinity is one of the major environmental factors causing crop yield loss worldwide. Different plants develop diverse salinity tolerance mechanisms to manage such a detrimental abiotic stress. The sand bean (Strophostyles helvola), a wild re...

Title: UNDERSTANDING BIAS IN NEXT-GENERATION SEQUENCING TECHNOLOGIES AND ANALYSES
Author: Price, Adam
Date Created: 2017
Subjects--Topical: Biology, Bioinformatics, Biophysics
Description: The problem of bias resulting from biological and technological sources is one that must be consistently reexamined alongside the development of new technologies and methods of analysis. This dissertation addresses the complexities of bias identif...

Title: Twinkle twinkle brittle star : the draft genome of Ophioderma brevispinum (Echinodermata: Ophiuroidea) as a resource for regeneration research
Author: Janies, Daniel, Machado, Denis Jacob, Reid, Robert, Kofsky, Janice
Date Created: 2022
Subjects--Topical: Genomics, Biology
Description: Background Echinoderms are established models in experimental and developmental biology, however genomic resources are still lacking for many species. Here, we present the draft genome of Ophioderma brevispinum, an emerging model organism in the f...

Title: Tracking a serial killer : integrating phylogenetic relationships, epidemiology, and geography for two invasive meningococcal disease outbreaks
Author: Janies, Daniel, Galac, Madeline R., Kilianski, Andrew
Date Created: 2018
Subjects--Topical: Communicable diseases, Biology
Description: Background While overall rates of meningococcal disease have been declining in the United States for the past several decades, New York City (NYC) has experienced two serogroup C meningococcal disease outbreaks in 2005-2006 and in 2010-2013. The o...

Title: Towards The Dry Preservation of Feline Sperm: The Effect Of Dehydration On DNA, Centrosomal Function, And Embryo Development
Author: Patrick, Jennifer
Date Created: 2016
Subjects--Topical: Biology
Description: The current gold standard for gamete preservation is cryogenic storage. Dry preservation is an attractive alternative, eliminating the need for refrigeration, reducing storage maintenance costs, and providing logistical flexibility for shipping. T...

Title: Toward understanding protein-DNA interactions
Author: Lin, Maoxuan
Date Created: 2020
Subjects--Topical: Biology, Bioinformatics, Biochemistry
Description: Knowledge of protein-DNA interactions has important implications in understandingbiological activities and developing therapeutic drugs. Two types of protein-DNAinteractions exist: (1) interactions between double-stranded DNA-binding proteins(DSBs...

Title: The induction of type-I interferon responses in primary osteoblasts following staphylococcus aureus infection
Author: Furr, Kelli
Date Created: 2022
Subjects--Topical: Biology
Description: Osteomyelitis is a serious bacterial infection of bone that is associated with progressive inflammatory tissue damage. This condition commonly affects the long bones of children along with the vertebrae and pelvis of adults. Staphylococcus aureus,...

Title: The in-vivo Evolution of Burkholderia multivorans in a Cystic Fibrosis patient
Author: Harrison, Sarah
Date Created: 2021
Subjects--Topical: Biology, Microbiology, Bioinformatics
Description: ABSTRACT Burkholderia multivorans is an opportunistic pathogen that poses a health risk to patients with cystic fibrosis (CF). The use of broad-range antibiotics to combat chronic bacterial lung infections has led to the evolution of antibiotic-re...

Title: The first complete mitochondrial genome of the sand dollar Sinaechinocyamus mai (Echinoidea: Clypeasteroida)
Author: Janies, Daniel, Machado, Denis Jacob
Date Created: 2020
Subjects--Topical: Genomics, Biology
Description: Morphologic and molecular data often lead to different hypotheses of phylogenetic relationships. Such incongruence has been found in the echinoderm class Echinoidea. In particular, the phylogenetic status of the order Clypeasteroida is not well re...

Title: The ecology of C-genotype and E-genotype strains of the bacterium Vibrio vulnificus and their interactions with the American oyster Crassostrea virginica
Author: Froelich, Brett
Date Created: 2012
Subjects--Topical: Biology, Microbiology
Description: Vibrio vulnificus is a pathogenic bacterium, routinely found in waters of estuarine environments as part of the normal microflora. This organism can be divided into two genotypes, a C-type associated with clinical isolation, and an E-type associat...

Title: The Role of the Cell Cycle in Karlodinium veneficum Toxicity: Tools and Predictions From the Laboratory
Author: Broemsen, Erik
Date Created: 2023
Subjects--Topical: Biology, Marine biology, Microbiology
Description: The toxic dinoflagellate Karlodinium veneficum forms blooms in estuaries worldwide. These blooms are often associated with severe fish mortalities that are largely caused by production of karlotoxins. The toxicity of these blooms can vary between ...

Title: The Role of Isometric Exercise Training on Reductions in Resting Blood Pressure: Human Trials and the Influence of Peripheral Vasoactive and Inflammatory Biomarkers
Author: Gordon, Benjamin
Date Created: 2012
Subjects--Topical: Biology, Kinesiology, Physiology
Description: Approximately 1 billion people worldwide and ~87 million adults in the United States alone are affected by hypertension [HTN: high blood pressure (HBP)]. Primary treatment avenues for HBP management include lifestyle modification (e.g. diet, exerc...

Title: The Relationship of Reproductive Hormones and Host Susceptibility to the Opportunistic Pathogen, Vibrio vulnificus
Author: McKee, Leslie
Date Created: 2015
Subjects--Topical: Biology, Microbiology, Endocrinology
Description: It is commonly found that males show a higher susceptibility to infectious diseases. While the underlying mechanism for this sex difference is not fully understood, one significant contributing attribute is the presence of specific sex hormones- e...