Search results | J. Murrey Atkins Library

Title: A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
Author: Wu, Shuta
Date Created: 2017
Subjects--Topical: Biology, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...

Title: A STRUCTURAL AND FUNCTIONAL ANALYSIS OF NEMATOSTELLA VECTENSIS MAJOR INTRINSIC PROTEINS
Author: Taylor, Jonathon
Date Created: 2020
Subjects--Topical: Biology, Cytology, Evolutionary developmental biology
Description: There is currently a major gap in understanding the physiological processes of tissue grade animals from early diverging phyla, particularly within the context of the molecular mechanisms in response to osmotic variation. A key protein family esse...

Title: ALGORITHMS FOR STRUCTURE BASED-PREDICTION OF TRANSCRIPTION FACTOR BINDING SITES
Author: Farrel, Alvin
Date Created: 2016
Subjects--Topical: Computer science, Biology, Bioinformatics
Description: Transcription factors (TFs) regulate gene expression through binding to specific target DNA sites. Accurate annotation of transcription factor binding sites (TFBSs) at genome scale represents an essential step toward our understanding of gene regu...

Title: APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
Author: HOSSAIN, MD AKRAM
Date Created: 2021
Subjects--Topical: Molecular biology, Biology, Cytology
Description: The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...

Title: ASSESSING COMPARATIVE FUNCTIONS FOR THE BZIP TRANSCRIPTION FACTOR NFE2 IN NEMATOSTELLA VECTENSIS
Author: Clegg, Devin
Date Created: 2020
Subjects--Topical: Biology
Description: The bZIP gene superfamily is a family of transcription factors that have gone through multiple duplication events within bilaterians, specifically in vertebrates. This has led to multiple paralogs in each bZIP family while early diverging phyla ha...

Title: Apoptotic T-cell derived microparticles containing sonic hedgehog modulate endothelial cell functions in inflammation via rho kinase pathway
Author: Attal, Neha
Date Created: 2019
Subjects--Topical: Biology
Description: Impaired vascular regulation as a result of endothelial dysfunction is a major determinant of sepsis-associated liver failure. We have previously shown that inhibition of one signaling molecule rho-kinase (ROCK) predominantly restores endothelial ...

Title: Assessing the impact of temperature on population-specific gene expression of a model estuarine cnidarian, Nematostella vectensis
Author: Klock, Amy
Date Created: 2020
Subjects--Topical: Biology
Description: Temperature is a critical environmental factor that affects all living organisms. Climate change is resulting in rising global temperatures with marine environments being especially vulnerable. My study aimed to elucidate the temperature-dependent...

Title: BIOFLAVONOIDS GENISTEIN AND QUERCETIN TRIGGER ALTERNATIVE END JOINING PATHWAY OF DNA REPAIR
Author: GHOSH, ANINDITA
Date Created: 2019
Subjects--Topical: Biology
Description: Faithful repair of chromosomal double-strand breaks (DSBs) is crucial to genome stability and normal cell survival and proliferation. During normal metabolic processes and especially following exposure to DNA damaging agents including irradiation,...

Title: CELLULAR BIOMARKER RESPONSES OF THE ASIAN CLAM, CORBICULA FLUMINEA, NEAR A COAL ASH POND
Author: Thomason, Travis
Date Created: 2018
Subjects--Topical: Biology
Description: The storage of coal combustion residuals (CCR) in aquatic surface impoundments has been a common practice across the United States for decades. Typically these aquatic surface impoundments are designed to allow the upper portion of the ash-basin w...

Title: CHARACTERIZATION OF THE BIOSYNTHETIC PATHWAY OF CAPSULAR POLYSACCHARIDE A IN BACTEROIDES FRAGILIS
Author: Sharma, Sunita
Date Created: 2019
Subjects--Topical: Molecular biology, Biology
Description: Capsular Polysaccharide A (CPSA) is a polymer of a tetrasaccharide unit found on the surface of the symbiotic gut bacteria Bacteroides fragilis. It has been suggested that CPSA is vital for maintaining a normal balance between the levels of Th1 an...

Title: CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL IMMUNOTHERAPY FOR MUCIN 1 (MUC1)-POSITIVE PANCREATIC DUCTAL ADENOCARCINOMA
Author: Yazdanifar, Mahboubeh
Date Created: 2019
Subjects--Topical: Biology
Description: Chimeric antigen receptor engineered (CAR) T cells have shown remarkable success in the treatment of hematologic cancers. However, this efficacy has yet to translate to treatment in solid tumors. Pancreatic ductal adenocarcinoma (PDA) is a fatal m...

Title: CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
Author: Knighton, Laura
Date Created: 2020
Subjects--Topical: Biology, Biochemistry
Description: The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...

Title: COMPARATIVE ANALYSIS OF REPEAT LANDSCAPES IN AVENA (OAT)
Author: Burkes, Shelvasha
Date Created: 2020
Subjects--Topical: Biology, Bioinformatics, Botany
Description: Avena sativa, or common oat, is a staple crop and member of the Poaceae or Grass family. Following behind wheat, maize and rice, oats account for 10.5 million hectares of the world’s produced crops as of 2017. Phytocompounds such as β-glucan, aven...

Title: CORTICAL ACTIVITY OF THE SENSORIMOTOR SYSTEM IN PARTICIPANTS WITH CHRONIC ANKLE INSTABILITY
Author: Burcal, Christopher
Date Created: 2017
Subjects--Topical: Biology, Kinesiology, Neurosciences
Description: Patients with chronic ankle instability (CAI) exhibit a wide variety of sensorimotor deficits. These include impairments in feed-forward sensorimotor control (i.e. motor planning) as well as feed-back sensorimotor control, which pertains to refini...

Title: Characterizing a New Regulator of the ATR Signaling Pathway
Author: Biller, Megan
Date Created: 2022
Subjects--Topical: Molecular biology, Biology
Description: Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...

Title: Collateral changes in susceptibility of Burkholderia multivorans
Author: Flanagan, Jerilyn
Date Created: 2019
Subjects--Topical: Biology, Microbiology
Description: Antibiotic resistant bacteria, particularly in chronic infections, are difficult and costly to treat, so research into detection, identification, and treatment options is critical. Susceptibility measurement must accurately reflect the degree to w...

Title: Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Author: Vestal, Carol
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...

Title: Comparative analysis of Nitrosococcus genomes; isolation, physiological and genomic characterization of the new ammonia-oxidizing species Nitrosococcus wardiae, strain D1FHST; and molecular studies towards a better understanding of ammonia-dependent chemolithotrophy
Author: Wang, Lin
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Obligate aerobic chemolithoautotrophic ammonia-oxidzing bacteria (AOB) derive energy and reductant needed for growth solely from the oxidation of ammonia to nitrite thereby facilitating the process of nitritation. A strain of an ammonia-oxidizing ...

Title: Cranial Capacity Variation of Pleistocene Homo and Possible Speciation Events
Author: Hudock, Autumn
Date Created: 2021
Subjects--Topical: Biology, Paleontology, Evolutionary developmental biology
Description: The field of paleoanthropology is tasked with studying the morphology of extinct hominins using fossilized remains. To study the evolution of the human brain, researchers use endocast data derived from fossil skulls, in order to assess when and ho...

Title: Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
Author: Fessler, Adam
Date Created: 2021
Subjects--Topical: Chemistry, Biology
Description: The growing interest in RNA biology, along with an expansion in computational capabilities, throughput, and sensitivity has provided researchers new tools to probe RNA. RNA selective 2′-hydroxy acylation analyzed by primer extension (SHAPE) utiliz...