Search results | J. Murrey Atkins Library

Title: A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
Author: Wu, Shuta
Date Created: 2017
Subjects--Topical: Biology, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...

Title: ALGORITHMS FOR STRUCTURE BASED-PREDICTION OF TRANSCRIPTION FACTOR BINDING SITES
Author: Farrel, Alvin
Date Created: 2016
Subjects--Topical: Computer science, Biology, Bioinformatics
Description: Transcription factors (TFs) regulate gene expression through binding to specific target DNA sites. Accurate annotation of transcription factor binding sites (TFBSs) at genome scale represents an essential step toward our understanding of gene regu...

Title: APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
Author: HOSSAIN, MD AKRAM
Date Created: 2021
Subjects--Topical: Molecular biology, Biology, Cytology
Description: The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...

Title: Apoptotic T-cell derived microparticles containing sonic hedgehog modulate endothelial cell functions in inflammation via rho kinase pathway
Author: Attal, Neha
Date Created: 2019
Subjects--Topical: Biology
Description: Impaired vascular regulation as a result of endothelial dysfunction is a major determinant of sepsis-associated liver failure. We have previously shown that inhibition of one signaling molecule rho-kinase (ROCK) predominantly restores endothelial ...

Title: BIOFLAVONOIDS GENISTEIN AND QUERCETIN TRIGGER ALTERNATIVE END JOINING PATHWAY OF DNA REPAIR
Author: GHOSH, ANINDITA
Date Created: 2019
Subjects--Topical: Biology
Description: Faithful repair of chromosomal double-strand breaks (DSBs) is crucial to genome stability and normal cell survival and proliferation. During normal metabolic processes and especially following exposure to DNA damaging agents including irradiation,...

Title: CHARACTERIZATION OF THE BIOSYNTHETIC PATHWAY OF CAPSULAR POLYSACCHARIDE A IN BACTEROIDES FRAGILIS
Author: Sharma, Sunita
Date Created: 2019
Subjects--Topical: Molecular biology, Biology
Description: Capsular Polysaccharide A (CPSA) is a polymer of a tetrasaccharide unit found on the surface of the symbiotic gut bacteria Bacteroides fragilis. It has been suggested that CPSA is vital for maintaining a normal balance between the levels of Th1 an...

Title: CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL IMMUNOTHERAPY FOR MUCIN 1 (MUC1)-POSITIVE PANCREATIC DUCTAL ADENOCARCINOMA
Author: Yazdanifar, Mahboubeh
Date Created: 2019
Subjects--Topical: Biology
Description: Chimeric antigen receptor engineered (CAR) T cells have shown remarkable success in the treatment of hematologic cancers. However, this efficacy has yet to translate to treatment in solid tumors. Pancreatic ductal adenocarcinoma (PDA) is a fatal m...

Title: CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
Author: Knighton, Laura
Date Created: 2020
Subjects--Topical: Biology, Biochemistry
Description: The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...

Title: COMPARATIVE ANALYSIS OF REPEAT LANDSCAPES IN AVENA (OAT)
Author: Burkes, Shelvasha
Date Created: 2020
Subjects--Topical: Biology, Bioinformatics, Botany
Description: Avena sativa, or common oat, is a staple crop and member of the Poaceae or Grass family. Following behind wheat, maize and rice, oats account for 10.5 million hectares of the world’s produced crops as of 2017. Phytocompounds such as β-glucan, aven...

Title: CORTICAL ACTIVITY OF THE SENSORIMOTOR SYSTEM IN PARTICIPANTS WITH CHRONIC ANKLE INSTABILITY
Author: Burcal, Christopher
Date Created: 2017
Subjects--Topical: Biology, Kinesiology, Neurosciences
Description: Patients with chronic ankle instability (CAI) exhibit a wide variety of sensorimotor deficits. These include impairments in feed-forward sensorimotor control (i.e. motor planning) as well as feed-back sensorimotor control, which pertains to refini...

Title: Collateral changes in susceptibility of Burkholderia multivorans
Author: Flanagan, Jerilyn
Date Created: 2019
Subjects--Topical: Biology, Microbiology
Description: Antibiotic resistant bacteria, particularly in chronic infections, are difficult and costly to treat, so research into detection, identification, and treatment options is critical. Susceptibility measurement must accurately reflect the degree to w...

Title: Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Author: Vestal, Carol
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...

Title: Comparative analysis of Nitrosococcus genomes; isolation, physiological and genomic characterization of the new ammonia-oxidizing species Nitrosococcus wardiae, strain D1FHST; and molecular studies towards a better understanding of ammonia-dependent chemolithotrophy
Author: Wang, Lin
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Obligate aerobic chemolithoautotrophic ammonia-oxidzing bacteria (AOB) derive energy and reductant needed for growth solely from the oxidation of ammonia to nitrite thereby facilitating the process of nitritation. A strain of an ammonia-oxidizing ...

Title: Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
Author: Fessler, Adam
Date Created: 2021
Subjects--Topical: Chemistry, Biology
Description: The growing interest in RNA biology, along with an expansion in computational capabilities, throughput, and sensitivity has provided researchers new tools to probe RNA. RNA selective 2′-hydroxy acylation analyzed by primer extension (SHAPE) utiliz...

Title: Detrimental brain inflammation and the role of the interleukin 10 family members
Author: Burmeister, Amanda
Date Created: 2019
Subjects--Topical: Biology
Description: Resident brain cells recognize pathogens and can initiate and/or regulate inflammation. Indeed, we have shown that stimulated glial cells rapidly produce inflammatory mediators, followed by the late production of anti-inflammatory cytokines such a...

Title: Disulfide-trapped CXCL12-CXCL4 Chemokine Heterodimers Prevent Breast Cancer Progression
Author: Nguyen, Khanh
Date Created: 2021
Subjects--Topical: Biology
Description: Triple negative breast cancers (TNBCs), i.e., 10-15% of diagnosed breast cancers, have a triple negative (Her/2-, ER- and PR-) phenotype and are the most aggressive subtype of breast cancer. TNBCs have a worst prognosis because of the high probabi...

Title: EFFECT OF CADMIUM AND SEASONALITY ON CRITICAL TEMPERATURES OF AEROBIC METABOLISM IN EASTERN OYSTERS, Crassostrea virginica Gmelin 1791
Author: Bagwe, Rita
Date Created: 2012
Subjects--Topical: Biology
Description: Cadmium (Cd) and elevated temperatures are common stressors in estuarine and coastal environments affecting intertidal mollusks such as oysters. Cd and elevated temperature can raise the metabolic demands of oysters due to the increase cost of det...

Title: EFFECTS OF S-ADENOSYL-L-METHIONINE ON COLLAGEN EXPRESSION IN ACTIVATED HEPATIC STELLATE CELLS
Author: Thompson, Kyle
Date Created: 2009
Subjects--Topical: Biology, Cytology
Description: Liver fibrosis is defined as the excessive accumulation of extracellular matrix (ECM) components, which can disrupt the normal liver microcirculation and lead to injury. Unresolved, hepatic fibrosis can progress to cirrhosis, an end-state liver di...

Title: EFFECTS OF SILIBININ ON ETHANOL-MEDIATED HEPATOCELLULAR CARCINOMA PROGRESSION IN MALE AND FEMALE MICE
Author: Warner, Elizabeth
Date Created: 2011
Subjects--Topical: Biology
Description: Ethanol is a significant risk for the development of hepatic cirrhosis and progression to hepatocellular carcinoma (HCC). While females are more susceptible to the deleterious effects of ethanol, the incidence of cirrhosis and HCC is significantly...

Title: EVALUATING BIOFLAVONOID INDUCED DNA DOUBLE-STRAND BREAKS AND CHROMOSOMAL TRANSLOCATIONS
Author: Goodenow, Donna
Date Created: 2020
Subjects--Topical: Biology
Description: Dietary bioflavonoids are a class of chemical compounds found in soy, fruits, vegetables, tea, coffee, wine, and dietary supplements. They are separated into 12 different sub-classes based upon their structure, however only six are dietarily relev...