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- Title
- A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
- Author
- Wu, Shuta
- Date Created
- 2017
- Subjects--Topical
- Biology, Oncology
- Description
- Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...
- Title
- A STRUCTURAL AND FUNCTIONAL ANALYSIS OF NEMATOSTELLA VECTENSIS MAJOR INTRINSIC PROTEINS
- Author
- Taylor, Jonathon
- Date Created
- 2020
- Subjects--Topical
- Biology, Cytology, Evolutionary developmental biology
- Description
- There is currently a major gap in understanding the physiological processes of tissue grade animals from early diverging phyla, particularly within the context of the molecular mechanisms in response to osmotic variation. A key protein family esse...
- Title
- A subterminal growth zone at arm tip likely underlies life-long indeterminate growth in brittle stars
- Author
- Janies, Daniel, Machado, Denis Jacob, Reid, Robert, Kofsky, Janice
- Date Created
- 2022
- Subjects--Topical
- Genomics, Biology
- Description
- Background Echinoderms are a phylum of marine invertebrates with close phylogenetic relationships to chordates. Many members of the phylum Echinodermata are capable of extensive post-traumatic regeneration and life-long indeterminate growth. Diffe...
- Title
- ALGORITHMS FOR STRUCTURE BASED-PREDICTION OF TRANSCRIPTION FACTOR BINDING SITES
- Author
- Farrel, Alvin
- Date Created
- 2016
- Subjects--Topical
- Computer science, Biology, Bioinformatics
- Description
- Transcription factors (TFs) regulate gene expression through binding to specific target DNA sites. Accurate annotation of transcription factor binding sites (TFBSs) at genome scale represents an essential step toward our understanding of gene regu...
- Title
- APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
- Author
- HOSSAIN, MD AKRAM
- Date Created
- 2021
- Subjects--Topical
- Molecular biology, Biology, Cytology
- Description
- The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...
- Title
- ASSESSING COMPARATIVE FUNCTIONS FOR THE BZIP TRANSCRIPTION FACTOR NFE2 IN NEMATOSTELLA VECTENSIS
- Author
- Clegg, Devin
- Date Created
- 2020
- Subjects--Topical
- Biology
- Description
- The bZIP gene superfamily is a family of transcription factors that have gone through multiple duplication events within bilaterians, specifically in vertebrates. This has led to multiple paralogs in each bZIP family while early diverging phyla ha...
- Title
- Active Notch signaling is required for arm regeneration in a brittle star
- Author
- Janies, Daniel, Machado, Denis Jacob, Reid, Robert
- Date Created
- 2020
- Subjects--Topical
- Genomics, Biology
- Description
- Cell signaling pathways play key roles in coordinating cellular events in development. The Notch signaling pathway is highly conserved across all multicellular animals and is known to coordinate a multitude of diverse cellular events, including pr...
- Title
- Apoptotic T-cell derived microparticles containing sonic hedgehog modulate endothelial cell functions in inflammation via rho kinase pathway
- Author
- Attal, Neha
- Date Created
- 2019
- Subjects--Topical
- Biology
- Description
- Impaired vascular regulation as a result of endothelial dysfunction is a major determinant of sepsis-associated liver failure. We have previously shown that inhibition of one signaling molecule rho-kinase (ROCK) predominantly restores endothelial ...
- Title
- Assessing the impact of temperature on population-specific gene expression of a model estuarine cnidarian, Nematostella vectensis
- Author
- Klock, Amy
- Date Created
- 2020
- Subjects--Topical
- Biology
- Description
- Temperature is a critical environmental factor that affects all living organisms. Climate change is resulting in rising global temperatures with marine environments being especially vulnerable. My study aimed to elucidate the temperature-dependent...
- Title
- BIOFLAVONOIDS GENISTEIN AND QUERCETIN TRIGGER ALTERNATIVE END JOINING PATHWAY OF DNA REPAIR
- Author
- GHOSH, ANINDITA
- Date Created
- 2019
- Subjects--Topical
- Biology
- Description
- Faithful repair of chromosomal double-strand breaks (DSBs) is crucial to genome stability and normal cell survival and proliferation. During normal metabolic processes and especially following exposure to DNA damaging agents including irradiation,...
- Title
- CELLULAR BIOMARKER RESPONSES OF THE ASIAN CLAM, CORBICULA FLUMINEA, NEAR A COAL ASH POND
- Author
- Thomason, Travis
- Date Created
- 2018
- Subjects--Topical
- Biology
- Description
- The storage of coal combustion residuals (CCR) in aquatic surface impoundments has been a common practice across the United States for decades. Typically these aquatic surface impoundments are designed to allow the upper portion of the ash-basin w...
- Title
- CHARACTERIZATION OF THE BIOSYNTHETIC PATHWAY OF CAPSULAR POLYSACCHARIDE A IN BACTEROIDES FRAGILIS
- Author
- Sharma, Sunita
- Date Created
- 2019
- Subjects--Topical
- Molecular biology, Biology
- Description
- Capsular Polysaccharide A (CPSA) is a polymer of a tetrasaccharide unit found on the surface of the symbiotic gut bacteria Bacteroides fragilis. It has been suggested that CPSA is vital for maintaining a normal balance between the levels of Th1 an...
- Title
- CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL IMMUNOTHERAPY FOR MUCIN 1 (MUC1)-POSITIVE PANCREATIC DUCTAL ADENOCARCINOMA
- Author
- Yazdanifar, Mahboubeh
- Date Created
- 2019
- Subjects--Topical
- Biology
- Description
- Chimeric antigen receptor engineered (CAR) T cells have shown remarkable success in the treatment of hematologic cancers. However, this efficacy has yet to translate to treatment in solid tumors. Pancreatic ductal adenocarcinoma (PDA) is a fatal m...
- Title
- CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
- Author
- Knighton, Laura
- Date Created
- 2020
- Subjects--Topical
- Biology, Biochemistry
- Description
- The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...
- Title
- COMPARATIVE ANALYSIS OF REPEAT LANDSCAPES IN AVENA (OAT)
- Author
- Burkes, Shelvasha
- Date Created
- 2020
- Subjects--Topical
- Biology, Bioinformatics, Botany
- Description
- Avena sativa, or common oat, is a staple crop and member of the Poaceae or Grass family. Following behind wheat, maize and rice, oats account for 10.5 million hectares of the world’s produced crops as of 2017. Phytocompounds such as β-glucan, aven...
- Title
- CORTICAL ACTIVITY OF THE SENSORIMOTOR SYSTEM IN PARTICIPANTS WITH CHRONIC ANKLE INSTABILITY
- Author
- Burcal, Christopher
- Date Created
- 2017
- Subjects--Topical
- Biology, Kinesiology, Neurosciences
- Description
- Patients with chronic ankle instability (CAI) exhibit a wide variety of sensorimotor deficits. These include impairments in feed-forward sensorimotor control (i.e. motor planning) as well as feed-back sensorimotor control, which pertains to refini...
- Title
- Calculating ensemble averaged descriptions of protein rigidity without sampling
- Author
- Jacobs, Donald J., Gonzalez, Luis C., Wang, Hui, Livesay, Dennis R.
- Date Created
- 2012
- Subjects--Topical
- Biology, Proteins
- Description
- Previous works have demonstrated that protein rigidity is related to thermodynamic stability, especially under conditions that favor formation of native structure. Mechanical network rigidity properties of a single conformation are efficiently cal...
- Title
- Characterizing a New Regulator of the ATR Signaling Pathway
- Author
- Biller, Megan
- Date Created
- 2022
- Subjects--Topical
- Molecular biology, Biology
- Description
- Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...
- Title
- Characterizing the diversity of heat shock proteins in Nematostella vectensis and Saccharomyces cerevisiae
- Author
- Alexander, William, Reitzel, Adam M., Truman, Andrew
- Date Created
- 2022
- Subjects--Topical
- Heat shock proteins, Biology
- Description
- Heat shock proteins (HSPs) are a highly conserved family of proteins critical to both environmental stress response and cellular function under normal conditions. More specifically HSPs are chaperone proteins that work to refold other misfolded pr...
- Title
- Chemoenzymatic preparation of a Campylobacter jejuni lipid-linked heptasaccharide on an azide-linked polyisoprenoid
- Author
- Reid, Amanda J., Erickson, Katelyn M., Hazel, Joseph M., Troutman, Jerry M.
- Date Created
- 2023
- Subjects--Topical
- Biology, Carbohydrates
- Description
- Complex poly- and oligosaccharides on the surface of bacteria provide a unique fingerprint to different strains of pathogenic and symbiotic microbes that could be exploited for therapeutics or sensors selective for specific glycans. To discover re...