Search results
- Title
- APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
- Author
- HOSSAIN, MD AKRAM
- Date Created
- 2021
- Subjects--Topical
- Molecular biology, Biology, Cytology
- Description
- The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...
- Title
- Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
- Author
- Bose, Mukulika
- Date Created
- 2022
- Subjects--Topical
- Molecular biology, Biochemistry, Oncology
- Description
- Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...
- Title
- CHARACTERIZATION OF THE BIOSYNTHETIC PATHWAY OF CAPSULAR POLYSACCHARIDE A IN BACTEROIDES FRAGILIS
- Author
- Sharma, Sunita
- Date Created
- 2019
- Subjects--Topical
- Molecular biology, Biology
- Description
- Capsular Polysaccharide A (CPSA) is a polymer of a tetrasaccharide unit found on the surface of the symbiotic gut bacteria Bacteroides fragilis. It has been suggested that CPSA is vital for maintaining a normal balance between the levels of Th1 an...
- Title
- Cell Type-Specific Double Strand Break Repair: An Inter-Chromosomal Homologous Recombination Study Using the Rainbow Mouse Model
- Author
- Lalwani, Kiran
- Date Created
- 2023
- Subjects--Topical
- Molecular biology, Cytology, Developmental biology
- Description
- Faithful repair of DNA lesions is central to maintaining genomic integrity. Illegitimate repair of chromosomal DNA damage, especially double-strand breaks (DSBs), can lead to mutations and genome rearrangements. Homologous recombination (HR) is a ...
- Title
- Characterizing a New Regulator of the ATR Signaling Pathway
- Author
- Biller, Megan
- Date Created
- 2022
- Subjects--Topical
- Molecular biology, Biology
- Description
- Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...
- Title
- Circadian behavior and gene expression in an estuarine cnidarian, Nematostella vectensis
- Author
- Leach, Whitney
- Date Created
- 2019
- Subjects--Topical
- Molecular biology, Ecology
- Description
- Animals respond to diurnal shifts in their environment with a combination of behavioral, physiological, and molecular changes to synchronize with regularly-timed external cues. The light:dark cycle is regarded as the most important entrainment cue...
- Title
- Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
- Author
- Vestal, Carol
- Date Created
- 2016
- Subjects--Topical
- Molecular biology, Biology, Genetics
- Description
- Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...
- Title
- Comparative analysis of Nitrosococcus genomes; isolation, physiological and genomic characterization of the new ammonia-oxidizing species Nitrosococcus wardiae, strain D1FHST; and molecular studies towards a better understanding of ammonia-dependent chemolithotrophy
- Author
- Wang, Lin
- Date Created
- 2016
- Subjects--Topical
- Molecular biology, Biology, Genetics
- Description
- Obligate aerobic chemolithoautotrophic ammonia-oxidzing bacteria (AOB) derive energy and reductant needed for growth solely from the oxidation of ammonia to nitrite thereby facilitating the process of nitritation. A strain of an ammonia-oxidizing ...
- Title
- Dissecting The Salivary Gland: Epithelial-Centered Dysfunction in Primary Sjögren’s Syndrome
- Author
- Noll, Braxton
- Date Created
- 2022
- Subjects--Topical
- Molecular biology
- Description
- Primary Sjögren’s syndrome (pSS) is an autoimmune disease of exocrine tissues causing dry mouth and eyes, mainly affecting women. A culmination of etiologic events leads to the loss of epithelial homeostasis resulting in the MMP9-mediated destruct...
- Title
- Dissecting functional differences in Hsp70 isoforms in nematostella vectensis
- Author
- Waller, Shawn
- Date Created
- 2018
- Subjects--Topical
- Molecular biology
- Description
- Heat shock protein 70s (Hsp70s) are a highly conserved class of molecular chaperones that are involved in cellular processes in all organisms such as stress response, homeostatic maintenance, and cell cycle progression. The organism Nematostella v...
- Title
- EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
- Author
- Seegers, Sara
- Date Created
- 2019
- Subjects--Topical
- Molecular biology, Virology, Biology
- Description
- Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...
- Title
- Genetic Structure and Gene Expression Profile of Plasmodium vivax in East Africa
- Author
- Kepple, Daniel
- Date Created
- 2022
- Subjects--Topical
- Biology, Molecular biology, Cytology
- Description
- Plasmodium vivax malaria is a neglected tropical disease, despite being more geographically widespread than any other form of malaria. P. vivax was previously thought to be rare or absent in Africa because people of African descent often lack the ...
- Title
- Hepatic Stellate Cell Transdifferentiation: Pro-fibrogenic Effectors
- Author
- Lakner, Ashley
- Date Created
- 2011
- Subjects--Topical
- Molecular biology, Biology
- Description
- Hepatic fibrosis is a significant cause of morbidity and mortality worldwide and can be described as exacerbated wound-healing marked by excessive deposition of extracellular matrix components, predominantly type I collagen. Chronic injury stimula...
- Title
- Inflammasome-driven IL-1ß and IL-18 cytokine signaling between macrophages and cancer cells within the breast tumor microenvironment
- Author
- Suryaprakash, Deepika
- Date Created
- 2018
- Subjects--Topical
- Molecular biology, Oncology
- Description
- Breast cancer especially triple-negative breast cancer remains deadly, despite detection, monitoring and therapeutic advances. Indeed, aggressive breast cancers metastasize to tissues including the brain, bones, and lungs. Metastasis is favored by...
- Title
- MOLECULAR MECHANISMS OF RESISTANCE OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS TO ONCOLYTIC VESICULAR STOMATITIS VIRUS
- Author
- Felt, Sebastien
- Date Created
- 2017
- Subjects--Topical
- Molecular biology, Virology, Cytology
- Description
- Oncolytic virus (OV) therapy is an anticancer therapy using replication-competent viruses selectively infecting, replicating in and killing cancer cells. Human pancreatic ductal adenocarcinoma (PDAC) cell lines are highly heterogeneous in their pe...
- Title
- Notch Serves as a Molecular Brake on Myogenesis, Protein Synthesis, and Growth in Skeletal Muscle
- Author
- Huot, Joshua
- Date Created
- 2018
- Subjects--Topical
- Molecular biology, Kinesiology
- Description
- Aging can be accompanied by aggressive loss of muscle mass (sarcopenia) and is a primary prognosticator for the reduced capacity of the elderly to accomplish basic activities of daily living. Several mechanisms within skeletal muscle lead to devel...
- Title
- Pleiotropic effects on the transcriptome and genome of transgenic soybeans resulting from transgene integration and expression in seed tissue
- Author
- Lambirth, Kevin
- Date Created
- 2015
- Subjects--Topical
- Molecular biology, Biology, Bioinformatics
- Description
- The seeds of the common soybean (Glycine max) produce and store large amounts of protein, making them an appealing bioreactor for producing valuable recombinant proteins at high levels. However, the effects of accumulating recombinant protein at h...
- Title
- Polymer Mediated Delivery of Oligonucleotide and Trans Genes Toward More Efficient and Specific Therapies for Dystrophinopathies and Dystroglycanopathies
- Author
- Tucker, Jason
- Date Created
- 2014
- Subjects--Topical
- Molecular biology, Biology, Neurosciences
- Description
- Muscular dystrophies are genetic disorders caused by mutations in more than 30 genes, with no cure or effective treatment. Duchenne muscular dystrophy (DMD) is caused by frame-shift mutations in the dystrophin gene with little or no functional dys...
- Title
- Production of Immunomodulatory Proteins in Glycine max for use in Diagnostics and as Therapeutics
- Author
- Powell, Rebecca
- Date Created
- 2010
- Subjects--Topical
- Molecular biology
- Description
- ABSTRACTREBECCA DIANE POWELL. Production of Immunomodulatory Proteins in Glycine max for Use in Diagnostics and as Therapeutics. (Under the direction of DR. KENNETH L. BOST) Immunomodulatory proteins can be utilized in diagnostic assays, as tolera...
- Title
- RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
- Author
- Daneshvar, Kaveh
- Date Created
- 2012
- Subjects--Topical
- Molecular biology, Biology, Genetics
- Description
- Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...