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Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
Title
Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
Author
Bose, Mukulika
Date Created
2022
Subjects--Topical
Molecular biology, Biochemistry, Oncology
Description
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...
CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
Title
CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
Author
Knighton, Laura
Date Created
2020
Subjects--Topical
Biology, Biochemistry
Description
The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...
Investigating the Genetic Basis and Selection of Diverse Plant Specialized Metabolites in Wild Soybean, Glycine soja.
Title
Investigating the Genetic Basis and Selection of Diverse Plant Specialized Metabolites in Wild Soybean, Glycine soja.
Author
Yasmin, Farida
Date Created
2023
Subjects--Topical
Botany, Genetics, Biochemistry
Description
Plant-specialized metabolites, such as glyceollins and soyasaponins, play vital roles in adapting to dynamic environments and promoting human health. Glyceollins, induced phytoalexins derived from the isoflavonoid branch of the phenylpropanoid pat...
Regulation of Myosin IIIa Motor/Kinase Activity
Title
Regulation of Myosin IIIa Motor/Kinase Activity
Author
Moore, Judy
Date Created
2009
Subjects--Topical
Biochemistry, Neurosciences, Cytology
Description
Myosin IIIa, a motor protein that localizes to actin-rich regions of photoreceptors and to stereocilia of inner ear hair cells, is associated with the hearing process in vertebrates and with phototransduction for invertebrates. It contains a large...
Role of Intramolecular Electrostatic Interactions on the Kinetics of Human Cardiac Myosin β-Isoform
Title
Role of Intramolecular Electrostatic Interactions on the Kinetics of Human Cardiac Myosin β-Isoform
Author
Gargey, Akhil
Date Created
2021
Subjects--Topical
Molecular biology, Biochemistry, Biophysics
Description
Human cardiac myosin has two isoforms, α and β, sharing significant sequence similarity, but different in kinetics. Small differences in the sequence are responsible for distinct local inter-residue interactions within α and β isoforms, leading to...
Understanding Chaperone interactions in disease
Title
Understanding Chaperone interactions in disease
Author
Nitika
Date Created
2021
Subjects--Topical
Molecular biology, Biochemistry, Cytology
Description
The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key player in proteostasis, deciding which proteins are foldable and which are too...
VPS501, A NOVEL SNX-BAR PROTEIN INVOLVED IN AUTOPHAGY
Title
VPS501, A NOVEL SNX-BAR PROTEIN INVOLVED IN AUTOPHAGY
Author
goyal, Shreya
Date Created
2021
Subjects--Topical
Biochemistry, Cytology, Molecular biology
Description
ABSTRACTCareful control of intracellular signaling pathways plays an important role in a cell’s ability to maintain stable internal conditions in the face of an ever-changing extracellular environment. This is particularly true as it relates to th...