Search results | J. Murrey Atkins Library

Title: APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
Author: HOSSAIN, MD AKRAM
Date Created: 2021
Subjects--Topical: Molecular biology, Biology, Cytology
Description: The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...

Title: Diagnostic Ultrasound Assessment of Femoral Cartilage Health in Individuals with Patellofemoral Pain
Author: Jeon, Hyunjae
Date Created: 2021
Subjects--Topical: Kinesiology
Description: Patients with patellofemoral pain (PFP) experience pain during or after physical activities. Recent evidence suggests PFP is not only a painful symptom which hinders daily activity but also a potential marker for future development of patellofemor...

Title: Disulfide-trapped CXCL12-CXCL4 Chemokine Heterodimers Prevent Breast Cancer Progression
Author: Nguyen, Khanh
Date Created: 2021
Subjects--Topical: Biology
Description: Triple negative breast cancers (TNBCs), i.e., 10-15% of diagnosed breast cancers, have a triple negative (Her/2-, ER- and PR-) phenotype and are the most aggressive subtype of breast cancer. TNBCs have a worst prognosis because of the high probabi...

Title: Effects of External Biofeedback on Biomechanics and Ankle Joint Health in Individuals With Chronic Ankle Instability
Author: Torp, Danielle
Date Created: 2021
Subjects--Topical: Kinesiology
Description: Individuals with chronic ankle instability (CAI) often demonstrate abnormal biomechanical patterns which may be associated with the onset of posttraumatic osteoarthritis (PTOA). There is a lack of interventions capable of changing gait impairments...

Title: Exploring the Immune System using Hybrid Cube Nanoparticles
Author: McMillan, Jessica
Date Created: 2021
Subjects--Topical: Biochemistry, Nanotechnology, Biology
Description: Nano-sized cubes made from nucleic acid material (NANPs) are ideal scaffolds for therapeutic nucleic acids (TNAs). Both utilize sequence specificity through base-pairing, providing controlled strand interaction, stability, and targeted targeting d...

Title: Inflammation, NLRP3 Inflammasomes, Macrophages and Breast Cancer Progression
Author: Holtzman , Katherine
Date Created: 2021
Subjects--Topical: Biology, Immunology, Oncology
Description: One in 8 women will be diagnosed with breast cancer in their lifetime and while breast cancer mortality has declined since the 1980s, it remains the 2nd leading cause of cancer-related deaths among women. Standard of care is determined by anatomic...

Title: Role of Intramolecular Electrostatic Interactions on the Kinetics of Human Cardiac Myosin β-Isoform
Author: Gargey, Akhil
Date Created: 2021
Subjects--Topical: Molecular biology, Biochemistry, Biophysics
Description: Human cardiac myosin has two isoforms, α and β, sharing significant sequence similarity, but different in kinetics. Small differences in the sequence are responsible for distinct local inter-residue interactions within α and β isoforms, leading to...

Title: Screening of FDA-Approved Drug Library for Combinatorial Treatment of Pancreatic Ductal Adenocarcinoma Cells with Oncolytic Vesicular Stomatitis Virus
Author: Holbrook, Molly
Date Created: 2021
Subjects--Topical: Biology
Description: Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with poor prognosis and a dismal survival rate, expected to become the second leading cause of cancer-related deaths in the United States. Oncolytic virus (OV) is an anticancer ap...

Title: Study of Enzymes Required for the Synthesis of the Enterobacterial Common Antigen in Vitro
Author: Oliverio, Cassidy
Date Created: 2021
Subjects--Topical: Biology
Description: In recent years, the Center for Disease Control (CDC) has highlighted many bacteria as being either serious or urgent threats in terms of antibiotic resistance such as Salmonella enterica, Klebsiella, and Shigella. These bacteria are all members o...

Title: The Role of Metformin on Non-Small Cell Lung Cancer Progression and Skeletal Muscle Health.
Author: Bond, Nicole
Date Created: 2021
Subjects--Topical: Molecular biology, Kinesiology
Description: Lung cancer is the second most common cancer and maintains a relatively small survival rate (~20%). Non-Small Cell Lung Cancer (NSCLC) makes up 80-85% of all lung cancer diagnoses. Lung cancer patients routinely undergo surgical procedures, chemot...

Title: The in-vivo Evolution of Burkholderia multivorans in a Cystic Fibrosis patient
Author: Harrison, Sarah
Date Created: 2021
Subjects--Topical: Biology, Microbiology, Bioinformatics
Description: ABSTRACT Burkholderia multivorans is an opportunistic pathogen that poses a health risk to patients with cystic fibrosis (CF). The use of broad-range antibiotics to combat chronic bacterial lung infections has led to the evolution of antibiotic-re...

Title: Understanding Chaperone interactions in disease
Author: Nitika
Date Created: 2021
Subjects--Topical: Molecular biology, Biochemistry, Cytology
Description: The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key player in proteostasis, deciding which proteins are foldable and which are too...

Title: VPS501, A NOVEL SNX-BAR PROTEIN INVOLVED IN AUTOPHAGY
Author: goyal, Shreya
Date Created: 2021
Subjects--Topical: Biochemistry, Cytology, Molecular biology
Description: ABSTRACTCareful control of intracellular signaling pathways plays an important role in a cell’s ability to maintain stable internal conditions in the face of an ever-changing extracellular environment. This is particularly true as it relates to th...