Search results
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Title
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A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
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Author
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Wu, Shuta
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Date Created
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2017
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Subjects--Topical
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Biology, Oncology
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Description
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Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...
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Title
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A STRUCTURAL AND FUNCTIONAL ANALYSIS OF NEMATOSTELLA VECTENSIS MAJOR INTRINSIC PROTEINS
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Author
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Taylor, Jonathon
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Date Created
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2020
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Subjects--Topical
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Biology, Cytology, Evolutionary developmental biology
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Description
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There is currently a major gap in understanding the physiological processes of tissue grade animals from early diverging phyla, particularly within the context of the molecular mechanisms in response to osmotic variation. A key protein family esse...
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Title
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ANCESTRAL COMPLEXITY AND LINEAGE SPECIFIC EXPANSIONS OF THE ANIMAL BZIP INTERACTOME
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Author
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Kane, Eric
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Date Created
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2017
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Subjects--Topical
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Bioinformatics, Evolutionary developmental biology
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Description
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Protein-protein interactions are central to the regulation and function of transcription factors in time- and cell-specific regulation of the genome. Increases in interactome complexity may serve as a mechanistic driver for evolutionary novelty. T...
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Title
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CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
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Author
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Knighton, Laura
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Date Created
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2020
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Subjects--Topical
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Biology, Biochemistry
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Description
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The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...
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Title
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CORTICAL ACTIVITY OF THE SENSORIMOTOR SYSTEM IN PARTICIPANTS WITH CHRONIC ANKLE INSTABILITY
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Author
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Burcal, Christopher
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Date Created
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2017
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Subjects--Topical
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Biology, Kinesiology, Neurosciences
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Description
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Patients with chronic ankle instability (CAI) exhibit a wide variety of sensorimotor deficits. These include impairments in feed-forward sensorimotor control (i.e. motor planning) as well as feed-back sensorimotor control, which pertains to refini...
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Title
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Characterizing a New Regulator of the ATR Signaling Pathway
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Author
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Biller, Megan
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Date Created
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2022
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Subjects--Topical
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Molecular biology, Biology
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Description
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Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...
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Title
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Circadian behavior and gene expression in an estuarine cnidarian, Nematostella vectensis
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Author
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Leach, Whitney
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Date Created
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2019
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Subjects--Topical
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Molecular biology, Ecology
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Description
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Animals respond to diurnal shifts in their environment with a combination of behavioral, physiological, and molecular changes to synchronize with regularly-timed external cues. The light:dark cycle is regarded as the most important entrainment cue...
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Title
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Collateral changes in susceptibility of Burkholderia multivorans
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Author
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Flanagan, Jerilyn
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Date Created
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2019
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Subjects--Topical
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Biology, Microbiology
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Description
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Antibiotic resistant bacteria, particularly in chronic infections, are difficult and costly to treat, so research into detection, identification, and treatment options is critical. Susceptibility measurement must accurately reflect the degree to w...