Search results | J. Murrey Atkins Library

Title: A STRUCTURAL AND FUNCTIONAL ANALYSIS OF NEMATOSTELLA VECTENSIS MAJOR INTRINSIC PROTEINS
Author: Taylor, Jonathon
Date Created: 2020
Subjects--Topical: Biology, Cytology, Evolutionary developmental biology
Description: There is currently a major gap in understanding the physiological processes of tissue grade animals from early diverging phyla, particularly within the context of the molecular mechanisms in response to osmotic variation. A key protein family esse...

Title: ANCESTRAL COMPLEXITY AND LINEAGE SPECIFIC EXPANSIONS OF THE ANIMAL BZIP INTERACTOME
Author: Kane, Eric
Date Created: 2017
Subjects--Topical: Bioinformatics, Evolutionary developmental biology
Description: Protein-protein interactions are central to the regulation and function of transcription factors in time- and cell-specific regulation of the genome. Increases in interactome complexity may serve as a mechanistic driver for evolutionary novelty. T...

Title: ASSESSING COMPARATIVE FUNCTIONS FOR THE BZIP TRANSCRIPTION FACTOR NFE2 IN NEMATOSTELLA VECTENSIS
Author: Clegg, Devin
Date Created: 2020
Subjects--Topical: Biology
Description: The bZIP gene superfamily is a family of transcription factors that have gone through multiple duplication events within bilaterians, specifically in vertebrates. This has led to multiple paralogs in each bZIP family while early diverging phyla ha...

Title: Assessing the impact of temperature on population-specific gene expression of a model estuarine cnidarian, Nematostella vectensis
Author: Klock, Amy
Date Created: 2020
Subjects--Topical: Biology
Description: Temperature is a critical environmental factor that affects all living organisms. Climate change is resulting in rising global temperatures with marine environments being especially vulnerable. My study aimed to elucidate the temperature-dependent...

Title: CELLULAR BIOMARKER RESPONSES OF THE ASIAN CLAM, CORBICULA FLUMINEA, NEAR A COAL ASH POND
Author: Thomason, Travis
Date Created: 2018
Subjects--Topical: Biology
Description: The storage of coal combustion residuals (CCR) in aquatic surface impoundments has been a common practice across the United States for decades. Typically these aquatic surface impoundments are designed to allow the upper portion of the ash-basin w...

Title: Characterizing a New Regulator of the ATR Signaling Pathway
Author: Biller, Megan
Date Created: 2022
Subjects--Topical: Molecular biology, Biology
Description: Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...

Title: Dissecting functional differences in Hsp70 isoforms in nematostella vectensis
Author: Waller, Shawn
Date Created: 2018
Subjects--Topical: Molecular biology
Description: Heat shock protein 70s (Hsp70s) are a highly conserved class of molecular chaperones that are involved in cellular processes in all organisms such as stress response, homeostatic maintenance, and cell cycle progression. The organism Nematostella v...

Title: Dry Preservation of Germinal Vesicles: Development of a New Formulation to Preserve DNA Integrity Under Adverse Environmental Conditions
Author: Orozco Cabral, Joseph
Date Created: 2022
Subjects--Topical: Biology, Bioengineering
Description: Advances in the cryopreservation of genetic material has revolutionized human reproductive medicine and animal conservation efforts. Despite many successes, oocytes have been more challenging to cryopreserve than sperm. Their large size makes it d...

Title: EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Author: Seegers, Sara
Date Created: 2019
Subjects--Topical: Molecular biology, Virology, Biology
Description: Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...

Title: Examining the Contribution of the DNA Damage Response to Sepsis Survivor Myelosuppression
Author: Huff, Laura
Date Created: 2020
Subjects--Topical: Immunology, Biology, Pathology
Description: A large portion of patients who survive sepsis, a life-threatening hyperinflammatory response to infection resulting in organ dysfunction, experience a higher risk of mortality than non-septic patients. Innate immune cells of sepsis survivors exhi...

Title: Exploring the Immune System using Hybrid Cube Nanoparticles
Author: McMillan, Jessica
Date Created: 2021
Subjects--Topical: Biochemistry, Nanotechnology, Biology
Description: Nano-sized cubes made from nucleic acid material (NANPs) are ideal scaffolds for therapeutic nucleic acids (TNAs). Both utilize sequence specificity through base-pairing, providing controlled strand interaction, stability, and targeted targeting d...

Title: Fibroblast-driven Fibrosis and Inflammation in Breast Cancer Progression
Author: Samuels, Courtney
Date Created: 2022
Subjects--Topical: Biology
Description: Breast cancer progression is promoted by both local inflammation and fibrosis. Indeed,accumulation of fibrous collagen is an independent prognosis marker of breast cancer. However, the mechanisms underlying the interplay between fibroblasts, infla...

Title: INVESTIGATING THE ROLE OF NEWLY DESCRIBED CYTOSOLIC PATTERN RECOGNITION RECEPTORS IN PROTECTIVE HOST RESPONSES TO NEUROTROPIC VIRUSES
Author: Crill, Emma
Date Created: 2014
Subjects--Topical: Immunology, Virology
Description: The importance of the effector functions performed by glial cells, the resident cells of the CNS possessing immune functions, in abrogating potentially fatal neurotropic viral infections have only recently begun to gain appreciation. These effecto...

Title: Inflammasome-driven IL-1ß and IL-18 cytokine signaling between macrophages and cancer cells within the breast tumor microenvironment
Author: Suryaprakash, Deepika
Date Created: 2018
Subjects--Topical: Molecular biology, Oncology
Description: Breast cancer especially triple-negative breast cancer remains deadly, despite detection, monitoring and therapeutic advances. Indeed, aggressive breast cancers metastasize to tissues including the brain, bones, and lungs. Metastasis is favored by...

Title: MACROPHAGES EXPRESSING NEUROPILIN-1 AND BREAST TUMOR PROGRESSION
Author: Helms, Rachel
Date Created: 2015
Subjects--Topical: Biology
Description: Human breast carcinoma is the most commonly diagnosed cancer in women in the United States with patient mortality primarily resulting from metastasis of breast cancer cells to distant organs. Immune cells, including macrophages, are involved in ca...

Title: Oral Microbiome Signature for Hematological Cancer
Author: Langdon, Holden
Date Created: 2020
Subjects--Topical: Biology
Description: BackgroundThe endogenous microbiome of healthy individuals in the oral cavity is diverse, representing over 700 different bacterial species. Some of these species may become opportunistic if certain elements in the microenvironment and host-respon...

Title: Polystyrene particle uptake and their potential to act as a trojan horse to oysters (Crassostrea virginica)
Author: Gaspar, Tamara
Date Created: 2017
Subjects--Topical: Environmental sciences, Ecology, Cytology
Description: The global annual usage of plastics has increased dramatically over the last decade. Polystyrene is the fourth most common plastic material produced annually due to its many versatile applications. Consequently, there has been a coinciding increas...

Title: Prevalence of Plasmodium vivax in Duffy-Negative Individuals Across Broad Regions of Ethiopia
Author: Little, Ebony
Date Created: 2023
Subjects--Topical: Biology
Description: Plasmodium parasites replicate asexually in the human host, and, in each replication cycle, a portion of the asexual stages develops into sexual gametocytes. The proportion of infections that carries gametocytes is a proxy for human-to-mosquito tr...

Title: REGULATION OF APE1 BY NEIL3 ZINC FINGER-GRF REPEAT ON SINGLE-STRANDED DNA
Author: Ha, Anh
Date Created: 2020
Subjects--Topical: Molecular biology, Cytology
Description: Base excision repair (BER) is a critical pathway in repairing single base lesions caused by oxidation, deamination, and alkylation. NEIL3 is a DNA glycosylase which functions in initiating BER pathway by recognizing and removing damaged bases. Alt...

Title: Screening of FDA-Approved Drug Library for Combinatorial Treatment of Pancreatic Ductal Adenocarcinoma Cells with Oncolytic Vesicular Stomatitis Virus
Author: Holbrook, Molly
Date Created: 2021
Subjects--Topical: Biology
Description: Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with poor prognosis and a dismal survival rate, expected to become the second leading cause of cancer-related deaths in the United States. Oncolytic virus (OV) is an anticancer ap...