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APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
Title
APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
Author
HOSSAIN, MD AKRAM
Date Created
2021
Subjects--Topical
Molecular biology, Biology, Cytology
Description
The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...
Understanding Chaperone interactions in disease
Title
Understanding Chaperone interactions in disease
Author
Nitika
Date Created
2021
Subjects--Topical
Molecular biology, Biochemistry, Cytology
Description
The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key player in proteostasis, deciding which proteins are foldable and which are too...
VPS501, A NOVEL SNX-BAR PROTEIN INVOLVED IN AUTOPHAGY
Title
VPS501, A NOVEL SNX-BAR PROTEIN INVOLVED IN AUTOPHAGY
Author
goyal, Shreya
Date Created
2021
Subjects--Topical
Biochemistry, Cytology, Molecular biology
Description
ABSTRACTCareful control of intracellular signaling pathways plays an important role in a cell’s ability to maintain stable internal conditions in the face of an ever-changing extracellular environment. This is particularly true as it relates to th...