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Immunostimulatory Properties of Nucleic Acid Nanoparticles
Title
Immunostimulatory Properties of Nucleic Acid Nanoparticles
Author
Halman, Justin
Date Created
2020
Subjects--Topical
Nanoscience
Description
Nucleic acids (DNA and RNA) are ubiquitous biomolecules found throughout all living organisms. They can act as genetic information storage and messengers, enzymes, molecular switches, and much more. Although DNA is used almost exclusively for its ...
Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Title
Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Author
Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created
2020
Subjects--Topical
Nucleic acids, Chemistry
Description
Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Title
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author
Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created
2020
Subjects--Topical
Nucleic acids, Chemistry
Description
Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...