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A virtual pebble game to ensemble average graph rigidity
Title
A virtual pebble game to ensemble average graph rigidity
Author
Jacobs, Donald J., Gonzalez, Luis C., Wang, Hui, Livesay, Dennis R.
Date Created
2015
Subjects--Topical
Probabilities, Proteins
Description
Background: The body-bar Pebble Game (PG) algorithm is commonly used to calculate network rigidity properties in proteins and polymeric materials. To account for fluctuating interactions such as hydrogen bonds, an ensemble of constraint topologies...
Rigidity emerges during antibody evolution in three distinct antibody systems: evidence from QSFR analysis of fab fragments
Title
Rigidity emerges during antibody evolution in three distinct antibody systems: evidence from QSFR analysis of fab fragments
Author
Jacobs, Donald J., Li, Tong, Livesay, Dennis R.
Date Created
2015
Subjects--Topical
Immunoglobulins, Biology
Description
The effects of somatic mutations that transform polyspecific germline (GL) antibodies to affinity mature (AM) antibodies with monospecificity are compared among three GL-AM Fab pairs. In particular, changes in conformational flexibility are assess...