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- Title
- A subterminal growth zone at arm tip likely underlies life-long indeterminate growth in brittle stars
- Author
- Janies, Daniel, Machado, Denis Jacob, Reid, Robert, Kofsky, Janice
- Date Created
- 2022
- Subjects--Topical
- Genomics, Biology
- Description
- Background Echinoderms are a phylum of marine invertebrates with close phylogenetic relationships to chordates. Many members of the phylum Echinodermata are capable of extensive post-traumatic regeneration and life-long indeterminate growth. Diffe...
- Title
- Detection of high prevalence of Plasmodium falciparum histidine-rich protein 2/3 gene deletions in Assosa zone, Ethiopia : implication for malaria diagnosis
- Author
- Janies, Daniel, Blackburn, Kayla, Lopez, Karen, Lo, Eugenia
- Date Created
- 2021
- Subjects--Topical
- Communicable diseases, Malaria
- Description
- Background Rapid diagnostic tests (RDTs) targeting histidine rich protein 2(HRP2) are widely used for diagnosis of Plasmodium falciparum infections. Besides PfHRP2, the PfHRP3 antigen contributes to the detection of P. falciparum infections in PfH...
- Title
- Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance
- Author
- Janies, Daniel, Lo, Eugenia, Kepple, Daniel
- Date Created
- 2019
- Subjects--Topical
- Communicable diseases, Malaria
- Description
- Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the ex...
- Title
- Gene polymorphisms among Plasmodium vivax geographical isolates and the potential as new biomarkers for gametocyte detection
- Author
- Janies, Daniel, Lo, Eugenia, Ford, Anthony
- Date Created
- 2022
- Subjects--Topical
- Genomics, Biology
- Description
- The unique biological features of Plasmodium vivax not only make it difficult to control but also to eliminate. For the transmission of the malaria parasite from infected human to the vector, gametocytes play a major role. The transmission potenti...
- Title
- Genetic variation of Plasmodium falciparum histidine-rich protein 2 and 3 in Assosa zone, Ethiopia : its impact on the performance of malaria rapid diagnostic tests
- Author
- Janies, Daniel, Blackburn, Kayla, Lopez, Karen, Lo, Eugenia
- Date Created
- 2021
- Subjects--Topical
- Communicable diseases, Malaria
- Description
- Background Rapid diagnostic tests (RDT) are commonly used for the diagnosis of malaria caused by Plasmodium falciparum. However, false negative results of RDT caused by genetic variation of P. falciparum histidine-rich protein 2 and 3 genes (pfhrp...
- Title
- Modeling Plasmodium falciparum diagnostic test sensitivity using machine learning with histidine-rich protein 2 variants
- Author
- Ford, Colby, Janies, Daniel, Alemayehu, Gezahegn, Lo, Eugenia, Blackburn, Kayla, Lopez, Karen, Dieng, Cheikh Cambel, Golassa, Lemu
- Subjects--Topical
- Malaria, Plasmodium falciparum
- Description
- Malaria, predominantly caused by Plasmodium falciparum, poses one of largest and most durable health threats in the world. Previously, simplistic regression-based models have been created to characterize malaria rapid diagnostic test performance, ...
- Title
- Patch dynamics modeling framework from pathogens' perspective : Unified and standardized approach for complicated epidemic systems
- Author
- Janies, Daniel, Chen, Shi, Lo, Eugenia, Dulin, Michael
- Date Created
- 2020
- Subjects--Topical
- Communicable diseases, Biology
- Description
- Mathematical models are powerful tools to investigate, simulate, and evaluate potential interventions for infectious diseases dynamics. Much effort has focused on the Susceptible-Infected-Recovered (SIR)-type compartment models. These models consi...
- Title
- Selection and utility of single nucleotide polymorphism markers to reveal fine-scale population structure in human malaria parasite Plasmodium falciparum
- Author
- Janies, Daniel, Lo, Eugenia, Ford, Anthony
- Date Created
- 2018
- Subjects--Topical
- Communicable diseases, Malaria
- Description
- Single nucleotide polymorphisms (SNPs) have been shown to be useful in revealing population structure with continental-and regional-scale samples. In epidemiological study, a careful selection of SNPs to track disease spread in local communities w...
- Title
- Twinkle twinkle brittle star : the draft genome of Ophioderma brevispinum (Echinodermata: Ophiuroidea) as a resource for regeneration research
- Author
- Janies, Daniel, Machado, Denis Jacob, Reid, Robert, Kofsky, Janice
- Date Created
- 2022
- Subjects--Topical
- Genomics, Biology
- Description
- Background Echinoderms are established models in experimental and developmental biology, however genomic resources are still lacking for many species. Here, we present the draft genome of Ophioderma brevispinum, an emerging model organism in the f...
- Title
- Venomix : a simple bioinformatic pipeline for identifying and characterizing toxin gene candidates from transcriptomic data
- Author
- Janies, Daniel, Reitzel, Adam M., Macrander, Jason
- Date Created
- 2018
- Subjects--Topical
- Genomics, Biology
- Description
- The advent of next-generation sequencing has resulted in transcriptome-based approaches to investigate functionally significant biological components in a variety of non-model organism. This has resulted in the area of venomics: a rapidly growing ...
- Title
- Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes
- Author
- Janies, Daniel, Lo, Eugenia, Ford, Anthony, Kepple, Daniel
- Date Created
- 2020
- Subjects--Topical
- Communicable diseases, Malaria
- Description
- Plasmodium vivax malaria is much less common in Africa than the rest of the world because the parasite relies primarily on the Duffy antigen/chemokine receptor (DARC) to invade human erythrocytes, and the majority of Africans are Duffy negative. R...