- Janies, Daniel (x)
- Chen, Shi (x)
- Lo, Eugenia (x)
- Search results
Search results
- Title
- Detection of high prevalence of Plasmodium falciparum histidine-rich protein 2/3 gene deletions in Assosa zone, Ethiopia : implication for malaria diagnosis
- Author
- Janies, Daniel, Blackburn, Kayla, Lopez, Karen, Lo, Eugenia
- Date Created
- 2021
- Subjects--Topical
- Communicable diseases, Malaria
- Description
- Background Rapid diagnostic tests (RDTs) targeting histidine rich protein 2(HRP2) are widely used for diagnosis of Plasmodium falciparum infections. Besides PfHRP2, the PfHRP3 antigen contributes to the detection of P. falciparum infections in PfH...
- Title
- Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance
- Author
- Janies, Daniel, Lo, Eugenia, Kepple, Daniel
- Date Created
- 2019
- Subjects--Topical
- Communicable diseases, Malaria
- Description
- Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the ex...
- Title
- Gene polymorphisms among Plasmodium vivax geographical isolates and the potential as new biomarkers for gametocyte detection
- Author
- Janies, Daniel, Lo, Eugenia, Ford, Anthony
- Date Created
- 2022
- Subjects--Topical
- Genomics, Biology
- Description
- The unique biological features of Plasmodium vivax not only make it difficult to control but also to eliminate. For the transmission of the malaria parasite from infected human to the vector, gametocytes play a major role. The transmission potenti...
- Title
- Genetic variation of Plasmodium falciparum histidine-rich protein 2 and 3 in Assosa zone, Ethiopia : its impact on the performance of malaria rapid diagnostic tests
- Author
- Janies, Daniel, Blackburn, Kayla, Lopez, Karen, Lo, Eugenia
- Date Created
- 2021
- Subjects--Topical
- Communicable diseases, Malaria
- Description
- Background Rapid diagnostic tests (RDT) are commonly used for the diagnosis of malaria caused by Plasmodium falciparum. However, false negative results of RDT caused by genetic variation of P. falciparum histidine-rich protein 2 and 3 genes (pfhrp...
- Title
- Modeling Plasmodium falciparum diagnostic test sensitivity using machine learning with histidine-rich protein 2 variants
- Author
- Ford, Colby, Janies, Daniel, Alemayehu, Gezahegn, Lo, Eugenia, Blackburn, Kayla, Lopez, Karen, Dieng, Cheikh Cambel, Golassa, Lemu
- Subjects--Topical
- Malaria, Plasmodium falciparum
- Description
- Malaria, predominantly caused by Plasmodium falciparum, poses one of largest and most durable health threats in the world. Previously, simplistic regression-based models have been created to characterize malaria rapid diagnostic test performance, ...
- Title
- Selection and utility of single nucleotide polymorphism markers to reveal fine-scale population structure in human malaria parasite Plasmodium falciparum
- Author
- Janies, Daniel, Lo, Eugenia, Ford, Anthony
- Date Created
- 2018
- Subjects--Topical
- Communicable diseases, Malaria
- Description
- Single nucleotide polymorphisms (SNPs) have been shown to be useful in revealing population structure with continental-and regional-scale samples. In epidemiological study, a careful selection of SNPs to track disease spread in local communities w...
- Title
- Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes
- Author
- Janies, Daniel, Lo, Eugenia, Ford, Anthony, Kepple, Daniel
- Date Created
- 2020
- Subjects--Topical
- Communicable diseases, Malaria
- Description
- Plasmodium vivax malaria is much less common in Africa than the rest of the world because the parasite relies primarily on the Duffy antigen/chemokine receptor (DARC) to invade human erythrocytes, and the majority of Africans are Duffy negative. R...