Search results | J. Murrey Atkins Library

Title: The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author: Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...

Title: Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Author: Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...

Title: Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Author: Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
Date Created: 2023
Subjects--Topical: Nucleic acids, Chemistry
Description: The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...

Title: Toll-like receptor-mediated recognition of nucleic acid nanoparticles (NANPs) in human primary blood cells
Author: Afonin, Kirill A., Truong, Nguyen, Halman, Justin
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry
Description: Infusion reactions (IRs) create a translational hurdle for many novel therapeutics, including those utilizing nanotechnology. Nucleic acid nanoparticles (NANPs) are a novel class of therapeutics prepared by rational design of relatively short olig...

Title: Alternate Reality Games (ARGs) as a lens of participatory learning and exposure to environmental racism in the United States
Author: Alabi, Mora, Fotiushang, Nikol
Date Created: 2023
Subjects--Topical: Alternate reality games, Environmental racism
Description: Contemporary educational models emphasize educators employ tools to increase engagement and collaborative thinking in student learning. Alternate Reality Games (ARGs) have recently been found to have great potential for language immersion and cult...

Title: Characterizing the diversity of heat shock proteins in Nematostella vectensis and Saccharomyces cerevisiae
Author: Alexander, William, Reitzel, Adam M., Truman, Andrew
Date Created: 2022
Subjects--Topical: Heat shock proteins, Biology
Description: Heat shock proteins (HSPs) are a highly conserved family of proteins critical to both environmental stress response and cellular function under normal conditions. More specifically HSPs are chaperone proteins that work to refold other misfolded pr...

Title: Quantifying reproductive behavior in the sea anemone Nematostella vectensis
Author: Alexander, William, Justin, Hannah, Reitzel, Adam M.
Date Created: 2022
Subjects--Topical: Cnidaria, Biology, Developmental biology, Marine biology, Sea anemones
Description: The Starlet Sea Anemone Nematostella vectensis (Nv) exists widely in coastal estuarine environments across North America. Nv has become a popular cnidarian model organism with a growing number of applications, including evolutionary developmental ...

Title: Multisensory integration by polymodal sensory neurons dictates larval settlement in a brainless cnidarian larva
Author: Birch, Sydney, Plachetzki, David
Date Created: 2023
Subjects--Topical: Biology, Developmental biology
Description: Multisensory integration (MSI) combines information from more than one sensory modality to elicit behaviours distinct from unisensory behaviours. MSI is best understood in animals with complex brains and specialized centres for parsing different m...

Title: Symbiotic life of echinoderm larvae
Author: Carrier, Tyler J., Reitzel, Adam M.
Date Created: 2020
Subjects--Topical: Symbiosis, Life sciences, Marine biology
Description: Echinoderms larvae have served as a fundamental system for understanding development and life history evolution over much of the last century. In the last few decades, our understanding of echinoderm larvae has expanded to the microbiota that they...

Title: Current perspectives of telomerase structure and function in eukaryotes with emerging views on telomerase in human parasites
Author: Chakrabarti, Kausik, Dey, Abhishek
Date Created: 2018
Subjects--Topical: Molecular biology, Evolution (Biology)
Description: Replicative capacity of a cell is strongly correlated with telomere length regulation. Aberrant lengthening or reduction in the length of telomeres can lead to health anomalies, such as cancer or premature aging. Telomerase is a master regulator f...

Title: In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei
Author: Chakrabarti, Kausik, Dey, Abishek, Klotz, Kaitlin, Davis, Justin, Monroy-Eklund, Anais, Saha, Arpita, Li, Bibo, Laederach, Alain
Subjects--Topical: RNA, Nucleoproteins
Description: Telomerase is a unique ribonucleoprotein (RNP) reverse transcriptase that utilizes its cognate RNA molecule as a template for telomere DNA repeat synthesis. Telomerase contains the reverse transcriptase protein, TERT and the template RNA, TR, as i...

Title: New perspectives on SNARE function in the yeast minimal endomembrane system
Author: Chi, Richard J., Grissom, James H., Segarra, Veronica A.
Subjects--Topical: Endocytosis, Cells
Description: Saccharomyces cerevisiae is one of the best model organisms for the study of endocytic membrane trafficking. While studies in mammalian cells have characterized the temporal and morphological features of the endocytic pathway, studies in budding y...

Title: Molecular mechanisms underlying glial inflammatory responses to Neisseria meningitidis
Author: Davis, Erin
Date Created: 2022, 2022, 2022
Subjects--Topical: Meningitis, Immune response

Title: The immunological capacity of thrombocytes
Author: Ferdous, Farzana, Scott, Thomas
Date Created: 2023
Subjects--Topical: Immune response, Blood platelets
Description: Thrombocytes are numerous in the blood of aves (birds) and ichthyoids (fish). The origin of this cell type is a common hematopoietic stem cell giving rise to a cell that is active in blood coagulation, inflammatory functions, and the immune respon...

Title: Modeling Plasmodium falciparum diagnostic test sensitivity using machine learning with histidine-rich protein 2 variants
Author: Ford, Colby, Janies, Daniel, Alemayehu, Gezahegn, Lo, Eugenia, Blackburn, Kayla, Lopez, Karen, Dieng, Cheikh Cambel, Golassa, Lemu
Subjects--Topical: Malaria, Plasmodium falciparum
Description: Malaria, predominantly caused by Plasmodium falciparum, poses one of largest and most durable health threats in the world. Previously, simplistic regression-based models have been created to characterize malaria rapid diagnostic test performance, ...

Title: Cellular bioreactivity of micro- and nano-plastic particles in oysters
Author: Gaspar, Tamara R., Chi, Richard J., Parrow, Matthew W., Ringwood, Amy H.
Subjects--Topical: Plastics, Nanoparticles
Description: The global usage of plastics has increased dramatically over the last several decades. Polystyrene (PS) is the fourth most common plastic material produced annually due to its many versatile applications. Consequently, there has been a coinciding ...

Title: Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Author: Grdzelishvili, Valery, Goad, Dakota, Bressy, Christian, Holbrook, Molly
Subjects--Topical: Vesicular stomatitis, Cancer, Viruses
Description: Vesicular stomatitis virus (VSV) is a promising oncolytic virus (OV) against different malignancies, including pancreatic ductal adenocarcinoma (PDAC). Our previous studies have demonstrated that VSV-based OVs are effective against the majority of...

Title: Cell cycle arrest in G2/M phase enhances replication of interferon-sensitive cytoplasmic RNA viruses via inhibition of antiviral gene expression
Author: Grdzelishvili, Valery, Bressy, Christian, Droby, Gaith N., Maldonado, Bryant D., Steuerwald, Nury
Subjects--Topical: Cancer, Viruses
Description: Vesicular stomatitis virus (VSV) (a rhabdovirus) and its variant VSV-ΔM51 are widely used model systems to study mechanisms of virus-host interactions. Here, we investigated how the cell cycle affects replication of these viruses using an array of...

Title: Combining oncolytic virotherapy with p53 tumor suppressor gene therapy
Author: Grdzelishvili, Valery, Bressy, Christian, Hastie, Eric Lawrence
Subjects--Topical: Cancer, Gene therapy
Description: Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. With the first U.S. Food and Drug Administration-approved OV, dozens of clinical trials ongoing, and an abundance of tr...

Title: Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Author: Grdzelishvili, Valery, Hastie, Eric Lawrence, Cataldi, Marcela, Moerdyk-Schauwecker, Megan J., Felt, Sebastien A., Steuerwald, Nury
Subjects--Topical: Cancer, Viruses
Description: Vesicular stomatitis virus (VSV) based recombinant viruses (such as VSV-ΔM51) are effective oncolytic viruses (OVs) against a majority of pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to VSV...