Search results
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Title
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A chromosome-level genome assembly of the highly heterozygous sea urchin Echinometra sp. EZ reveals adaptation in the regulatory regions of stress response genes
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Author
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Reitzel, Adam M., Ketchum, Remi, Smith, Edward, Davidson, Phillip L.
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Date Created
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2022
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Subjects--Topical
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Sea urchins, Echinodermata
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Description
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Echinometra is the most widespread genus of sea urchin and has been the focus of a wide range of studies in ecology, speciation, and reproduction. However, available genetic data for this genus are generally limited to a few select loci. Here, we ...
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Title
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A comparison of transgenic and wild type soybean seeds : analysis of transcriptome profiles using RNA-Seq
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Author
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Loraine, Ann, Lambirth, Kevin C., Whaley, Adam M., Piller, Kenneth J.
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Date Created
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2015
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Subjects--Topical
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Gene expression, Biotechnology
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Description
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Background: Soybean (Glycine max) has been bred for thousands of years to produce seeds rich in protein for human and animal consumption, making them an appealing bioreactor for producing valuable recombinant proteins at high levels. However, the ...
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Title
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A new obligate CXCL4-CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms
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Author
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Nesmelova, Irina, Ngyuen, Khanh T.P., Dreau, Didier, Volkman, Brian
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Date Created
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2022
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Subjects--Topical
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Chemokines, Proteins
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Description
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Chemokines form a family of proteins with critical roles in many biological processes in health and disease conditions, including cardiovascular, autoimmune diseases, infections, and cancer. Many chemokines engage in heterophilic interactions to f...
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Title
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APE2 promotes DNA damage response pathway from a single-strand break
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Author
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Yan, Shan, Lin, Yunfeng, Bai, Liping, Cupello, Steven
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Date Created
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2018
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Subjects--Topical
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Cancer--Research, DNA
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Description
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As the most common type of DNA damage, DNA single-strand breaks (SSBs) are primarily repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaired SSBs lead to genome stability and have been implicated in cancer and neurod...
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Title
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Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
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Author
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Grdzelishvili, Valery, Goad, Dakota, Bressy, Christian, Holbrook, Molly
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Subjects--Topical
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Vesicular stomatitis, Cancer, Viruses
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Description
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Vesicular stomatitis virus (VSV) is a promising oncolytic virus (OV) against different malignancies, including pancreatic ductal adenocarcinoma (PDAC). Our previous studies have demonstrated that VSV-based OVs are effective against the majority of...
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Title
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Cell cycle arrest in G2/M phase enhances replication of interferon-sensitive cytoplasmic RNA viruses via inhibition of antiviral gene expression
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Author
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Grdzelishvili, Valery, Bressy, Christian, Droby, Gaith N., Maldonado, Bryant D., Steuerwald, Nury
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Subjects--Topical
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Cancer, Viruses
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Description
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Vesicular stomatitis virus (VSV) (a rhabdovirus) and its variant VSV-ΔM51 are widely used model systems to study mechanisms of virus-host interactions. Here, we investigated how the cell cycle affects replication of these viruses using an array of...
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Title
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Cellular bioreactivity of micro- and nano-plastic particles in oysters
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Author
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Gaspar, Tamara R., Chi, Richard J., Parrow, Matthew W., Ringwood, Amy H.
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Subjects--Topical
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Plastics, Nanoparticles
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Description
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The global usage of plastics has increased dramatically over the last several decades. Polystyrene (PS) is the fourth most common plastic material produced annually due to its many versatile applications. Consequently, there has been a coinciding ...
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Title
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Combining oncolytic virotherapy with p53 tumor suppressor gene therapy
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Author
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Grdzelishvili, Valery, Bressy, Christian, Hastie, Eric Lawrence
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Subjects--Topical
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Cancer, Gene therapy
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Description
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Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. With the first U.S. Food and Drug Administration-approved OV, dozens of clinical trials ongoing, and an abundance of tr...
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Title
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Creating an online scientific art exhibit formatted for people with a visual impairment
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Author
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Sorrell, Melanie, Norton, Derek R., McAdams, Jeff, Winterling, Rachael, Dipple, Kathleen
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Subjects--Topical
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People with visual disabilities, Accessible Web sites for people with disabilities, Academic libraries
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Description
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An online exhibit accessible by people with a visual impairment was created to accompany a university library’s physical exhibit of microscopic images generated by researchers on campus as “scientific art.” This online exhibit consisted of a Web p...
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Title
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Cytosolic DNA sensors and CNS responses to viral pathogens
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Author
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Marriott, Ian, Jeffries, Austin
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Subjects--Topical
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DNA, Virus diseases
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Description
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Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
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Title
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Cytosolic DNA sensors and glial responses to endogenous DNA
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Author
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Marriott, Ian, Suptela, Alexander J.
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Date Created
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2023
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Subjects--Topical
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Genomics, DNA
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Description
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Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic integrity ...
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Title
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Daily cycle in oxygen consumption by the sea anemone Nematostella vectensis Stephenson
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Author
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Reitzel, Adam M., Maas, Amy E., Jones, Ian T.
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Date Created
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2016
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Subjects--Topical
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Gene expression, Biology
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Description
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In bilaterian animals, the circadian clock is intimately involved in regulating energetic metabolism. Although cnidarians exhibit diel behavioral rhythms including cycles in locomotor activity, tentacle extension and spawning, daily cycles in cnid...
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Title
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Decoupling behavioral and transcriptional responses to color in an eyeless cnidarian
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Author
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Reitzel, Adam M., Leach, Whitney
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Subjects--Topical
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Gene expression, Circadian rhythms
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Description
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Background Animals have specific molecular, physiological, and behavioral responses to light that are influenced by wavelength and intensity. Predictable environmental changes – predominantly solar and lunar cycles – drive endogenous daily oscilla...
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Title
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Detection of high prevalence of Plasmodium falciparum histidine-rich protein 2/3 gene deletions in Assosa zone, Ethiopia : implication for malaria diagnosis
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Author
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Janies, Daniel, Blackburn, Kayla, Lopez, Karen, Lo, Eugenia
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Date Created
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2021
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Subjects--Topical
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Communicable diseases, Malaria
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Description
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Background Rapid diagnostic tests (RDTs) targeting histidine rich protein 2(HRP2) are widely used for diagnosis of Plasmodium falciparum infections. Besides PfHRP2, the PfHRP3 antigen contributes to the detection of P. falciparum infections in PfH...