Search results | J. Murrey Atkins Library

Title: EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Author: Seegers, Sara
Date Created: 2019
Subjects--Topical: Molecular biology, Virology, Biology
Description: Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...

Title: RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
Author: Daneshvar, Kaveh
Date Created: 2012
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...

Title: Production of Immunomodulatory Proteins in Glycine max for use in Diagnostics and as Therapeutics
Author: Powell, Rebecca
Date Created: 2010
Subjects--Topical: Molecular biology
Description: ABSTRACTREBECCA DIANE POWELL. Production of Immunomodulatory Proteins in Glycine max for Use in Diagnostics and as Therapeutics. (Under the direction of DR. KENNETH L. BOST) Immunomodulatory proteins can be utilized in diagnostic assays, as tolera...

Title: Polymer Mediated Delivery of Oligonucleotide and Trans Genes Toward More Efficient and Specific Therapies for Dystrophinopathies and Dystroglycanopathies
Author: Tucker, Jason
Date Created: 2014
Subjects--Topical: Molecular biology, Biology, Neurosciences
Description: Muscular dystrophies are genetic disorders caused by mutations in more than 30 genes, with no cure or effective treatment. Duchenne muscular dystrophy (DMD) is caused by frame-shift mutations in the dystrophin gene with little or no functional dys...

Title: Pleiotropic effects on the transcriptome and genome of transgenic soybeans resulting from transgene integration and expression in seed tissue
Author: Lambirth, Kevin
Date Created: 2015
Subjects--Topical: Molecular biology, Biology, Bioinformatics
Description: The seeds of the common soybean (Glycine max) produce and store large amounts of protein, making them an appealing bioreactor for producing valuable recombinant proteins at high levels. However, the effects of accumulating recombinant protein at h...

Title: ROLE OF AQUAPORINS DURING HEPATOCELLULAR CARCINOMA INITIATION AND PROGRESSION
Author: Mattocks, Matthew
Date Created: 2010
Subjects--Topical: Molecular biology, Cytology, Oncology
Description: Aquaporins (AQPs) are ubiquitously expressed proteinaceous water channels involved in numerous physiological processes including bile production and apoptosis. Aquaporins 8 and 9 are expressed in hepatocytes, and are down regulated in a rat model ...

Title: Notch Serves as a Molecular Brake on Myogenesis, Protein Synthesis, and Growth in Skeletal Muscle
Author: Huot, Joshua
Date Created: 2018
Subjects--Topical: Molecular biology, Kinesiology
Description: Aging can be accompanied by aggressive loss of muscle mass (sarcopenia) and is a primary prognosticator for the reduced capacity of the elderly to accomplish basic activities of daily living. Several mechanisms within skeletal muscle lead to devel...

Title: REGULATION OF APE1 BY NEIL3 ZINC FINGER-GRF REPEAT ON SINGLE-STRANDED DNA
Author: Ha, Anh
Date Created: 2020
Subjects--Topical: Molecular biology, Cytology
Description: Base excision repair (BER) is a critical pathway in repairing single base lesions caused by oxidation, deamination, and alkylation. NEIL3 is a DNA glycosylase which functions in initiating BER pathway by recognizing and removing damaged bases. Alt...

Title: Dissecting The Salivary Gland: Epithelial-Centered Dysfunction in Primary Sjögren’s Syndrome
Author: Noll, Braxton
Date Created: 2022
Subjects--Topical: Molecular biology
Description: Primary Sjögren’s syndrome (pSS) is an autoimmune disease of exocrine tissues causing dry mouth and eyes, mainly affecting women. A culmination of etiologic events leads to the loss of epithelial homeostasis resulting in the MMP9-mediated destruct...

Title: Dissecting functional differences in Hsp70 isoforms in nematostella vectensis
Author: Waller, Shawn
Date Created: 2018
Subjects--Topical: Molecular biology
Description: Heat shock protein 70s (Hsp70s) are a highly conserved class of molecular chaperones that are involved in cellular processes in all organisms such as stress response, homeostatic maintenance, and cell cycle progression. The organism Nematostella v...

Title: Comparative analysis of Nitrosococcus genomes; isolation, physiological and genomic characterization of the new ammonia-oxidizing species Nitrosococcus wardiae, strain D1FHST; and molecular studies towards a better understanding of ammonia-dependent chemolithotrophy
Author: Wang, Lin
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Obligate aerobic chemolithoautotrophic ammonia-oxidzing bacteria (AOB) derive energy and reductant needed for growth solely from the oxidation of ammonia to nitrite thereby facilitating the process of nitritation. A strain of an ammonia-oxidizing ...

Title: Hepatic Stellate Cell Transdifferentiation: Pro-fibrogenic Effectors
Author: Lakner, Ashley
Date Created: 2011
Subjects--Topical: Molecular biology, Biology
Description: Hepatic fibrosis is a significant cause of morbidity and mortality worldwide and can be described as exacerbated wound-healing marked by excessive deposition of extracellular matrix components, predominantly type I collagen. Chronic injury stimula...

Title: MOLECULAR MECHANISMS OF RESISTANCE OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS TO ONCOLYTIC VESICULAR STOMATITIS VIRUS
Author: Felt, Sebastien
Date Created: 2017
Subjects--Topical: Molecular biology, Virology, Cytology
Description: Oncolytic virus (OV) therapy is an anticancer therapy using replication-competent viruses selectively infecting, replicating in and killing cancer cells. Human pancreatic ductal adenocarcinoma (PDAC) cell lines are highly heterogeneous in their pe...

Title: Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
Author: Bose, Mukulika
Date Created: 2022
Subjects--Topical: Molecular biology, Biochemistry, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...

Title: Genetic Structure and Gene Expression Profile of Plasmodium vivax in East Africa
Author: Kepple, Daniel
Date Created: 2022
Subjects--Topical: Biology, Molecular biology, Cytology
Description: Plasmodium vivax malaria is a neglected tropical disease, despite being more geographically widespread than any other form of malaria. P. vivax was previously thought to be rare or absent in Africa because people of African descent often lack the ...

Title: CHARACTERIZATION OF THE BIOSYNTHETIC PATHWAY OF CAPSULAR POLYSACCHARIDE A IN BACTEROIDES FRAGILIS
Author: Sharma, Sunita
Date Created: 2019
Subjects--Topical: Molecular biology, Biology
Description: Capsular Polysaccharide A (CPSA) is a polymer of a tetrasaccharide unit found on the surface of the symbiotic gut bacteria Bacteroides fragilis. It has been suggested that CPSA is vital for maintaining a normal balance between the levels of Th1 an...

Title: Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Author: Vestal, Carol
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...

Title: Circadian behavior and gene expression in an estuarine cnidarian, Nematostella vectensis
Author: Leach, Whitney
Date Created: 2019
Subjects--Topical: Molecular biology, Ecology
Description: Animals respond to diurnal shifts in their environment with a combination of behavioral, physiological, and molecular changes to synchronize with regularly-timed external cues. The light:dark cycle is regarded as the most important entrainment cue...

Title: APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
Author: HOSSAIN, MD AKRAM
Date Created: 2021
Subjects--Topical: Molecular biology, Biology, Cytology
Description: The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...

Title: The role of the dopaminergic system in the regulation of physical activity in mice
Author: Knab, Amy
Date Created: 2009
Subjects--Topical: Molecular biology, Genetics, Physiology
Description: Physical activity (PA) is important to human health, and the genetic and biological regulating factors of physical activity are only beginning to be understood. The dopamine (DA) system has been shown to regulate motivation, and locomotor behavior...