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EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Title
EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Author
Seegers, Sara
Date Created
2019
Subjects--Topical
Molecular biology, Virology, Biology
Description
Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...
HOST FACTORS CONTROLLING VIRUS INFECTION: IMPLICATIONS FOR ANTIVIRALS AND VIROTHERAPY
Title
HOST FACTORS CONTROLLING VIRUS INFECTION: IMPLICATIONS FOR ANTIVIRALS AND VIROTHERAPY
Author
Shah, Nirav
Date Created
2013
Subjects--Topical
Virology, Oncology
Description
Viruses are obligate intracellular parasites rely heavily on host components and pathways for their replication. Studying different cellular factors affecting viral infection can enable us to identify novel drug targets, improve current antiviral ...
MUC1 MEDIATED SIGNALING IN PANCREATIC DUCTAL ADENOCARCINOMA
Title
MUC1 MEDIATED SIGNALING IN PANCREATIC DUCTAL ADENOCARCINOMA
Author
Grover, Priyanka
Date Created
2019
Subjects--Topical
Biology
Description
In 2019, Pancreatic Cancer (PC) is the 3rd leading cause of cancer-related deaths in the USA with 94% dying within 5 years of diagnosis. 90% of PC is Pancreatic Ductal Adenocarcinoma (PDA), of which >80% overexpress a hypo-glycosylated form the me...
MOLECULAR MECHANISMS OF RESISTANCE OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS TO ONCOLYTIC VESICULAR STOMATITIS VIRUS
Title
MOLECULAR MECHANISMS OF RESISTANCE OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS TO ONCOLYTIC VESICULAR STOMATITIS VIRUS
Author
Felt, Sebastien
Date Created
2017
Subjects--Topical
Molecular biology, Virology, Cytology
Description
Oncolytic virus (OV) therapy is an anticancer therapy using replication-competent viruses selectively infecting, replicating in and killing cancer cells. Human pancreatic ductal adenocarcinoma (PDAC) cell lines are highly heterogeneous in their pe...
A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
Title
A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
Author
Wu, Shuta
Date Created
2017
Subjects--Topical
Biology, Oncology
Description
Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...
CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL IMMUNOTHERAPY FOR MUCIN 1 (MUC1)-POSITIVE PANCREATIC DUCTAL ADENOCARCINOMA
Title
CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL IMMUNOTHERAPY FOR MUCIN 1 (MUC1)-POSITIVE PANCREATIC DUCTAL ADENOCARCINOMA
Author
Yazdanifar, Mahboubeh
Date Created
2019
Subjects--Topical
Biology
Description
Chimeric antigen receptor engineered (CAR) T cells have shown remarkable success in the treatment of hematologic cancers. However, this efficacy has yet to translate to treatment in solid tumors. Pancreatic ductal adenocarcinoma (PDA) is a fatal m...
TRANSCRIPTIONAL REGULATION OF GENES ASSOCIATED WITH DRUG RESISTANCE AND GROWTH OF PANCREATIC CANCER CELLS BY MUCIN 1
Title
TRANSCRIPTIONAL REGULATION OF GENES ASSOCIATED WITH DRUG RESISTANCE AND GROWTH OF PANCREATIC CANCER CELLS BY MUCIN 1
Author
Nath, Sritama
Date Created
2013
Subjects--Topical
Molecular biology, Cytology, Oncology
Description
Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US. An understanding of the molecular pathogenesis of PDA is of utmost importance to be able to improve the current or design new targeted therapies fo...