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RANK-L expression in Staphylococcus aureus- induced osteomyelitis, therapeutic intervention using nanotechnology and use of UV-killed bacteria as an osteoconductive coating for biomaterials.
Title
RANK-L expression in Staphylococcus aureus- induced osteomyelitis, therapeutic intervention using nanotechnology and use of UV-killed bacteria as an osteoconductive coating for biomaterials.
Author
Somayaji, Shankari
Date Created
2009
Subjects--Topical
Microbiology
Description
Staphylococcus aureus is responsible for approximately 80% of all cases of human osteomyelitis. RANK-L is an essential signal produced by osteoblasts and is required for full osteoclastic differentiation. PGE2 - induced bone resorption involves bo...
IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Title
IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
Author
Benedetto, Gregory
Date Created
2015
Subjects--Topical
Chemistry, Biology
Description
New clinical tools that aid in the early diagnosis of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of the work presented here was to identify ovarian tumor specific singl...
Exploring the Immune System using Hybrid Cube Nanoparticles
Title
Exploring the Immune System using Hybrid Cube Nanoparticles
Author
McMillan, Jessica
Date Created
2021
Subjects--Topical
Biochemistry, Nanotechnology, Biology
Description
Nano-sized cubes made from nucleic acid material (NANPs) are ideal scaffolds for therapeutic nucleic acids (TNAs). Both utilize sequence specificity through base-pairing, providing controlled strand interaction, stability, and targeted targeting d...
A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
Title
A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
Author
Wu, Shuta
Date Created
2017
Subjects--Topical
Biology, Oncology
Description
Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...