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Detrimental brain inflammation and the role of the interleukin 10 family members
Title
Detrimental brain inflammation and the role of the interleukin 10 family members
Author
Burmeister, Amanda
Date Created
2019
Subjects--Topical
Biology
Description
Resident brain cells recognize pathogens and can initiate and/or regulate inflammation. Indeed, we have shown that stimulated glial cells rapidly produce inflammatory mediators, followed by the late production of anti-inflammatory cytokines such a...
Exploring the Immune System using Hybrid Cube Nanoparticles
Title
Exploring the Immune System using Hybrid Cube Nanoparticles
Author
McMillan, Jessica
Date Created
2021
Subjects--Topical
Biochemistry, Nanotechnology, Biology
Description
Nano-sized cubes made from nucleic acid material (NANPs) are ideal scaffolds for therapeutic nucleic acids (TNAs). Both utilize sequence specificity through base-pairing, providing controlled strand interaction, stability, and targeted targeting d...
Inflammasome-driven IL-1ß and IL-18 cytokine signaling between macrophages and cancer cells within the breast tumor microenvironment
Title
Inflammasome-driven IL-1ß and IL-18 cytokine signaling between macrophages and cancer cells within the breast tumor microenvironment
Author
Suryaprakash, Deepika
Date Created
2018
Subjects--Topical
Molecular biology, Oncology
Description
Breast cancer especially triple-negative breast cancer remains deadly, despite detection, monitoring and therapeutic advances. Indeed, aggressive breast cancers metastasize to tissues including the brain, bones, and lungs. Metastasis is favored by...
Inflammation, NLRP3 Inflammasomes, Macrophages and Breast Cancer Progression
Title
Inflammation, NLRP3 Inflammasomes, Macrophages and Breast Cancer Progression
Author
Holtzman , Katherine
Date Created
2021
Subjects--Topical
Biology, Immunology, Oncology
Description
One in 8 women will be diagnosed with breast cancer in their lifetime and while breast cancer mortality has declined since the 1980s, it remains the 2nd leading cause of cancer-related deaths among women. Standard of care is determined by anatomic...
Newly described cytosolic pattern recognition receptors mediate inflammatory glial responses to neurotropic viruses
Title
Newly described cytosolic pattern recognition receptors mediate inflammatory glial responses to neurotropic viruses
Author
Furr, Samantha
Date Created
2012
Subjects--Topical
Immunology, Biology
Description
The rapid onset of potentially lethal neuroinflammation is a defining feature of viral encephalitis. Glial cells are ideally positioned to respond to invading pathogens of the central nervous system (CNS) and produce key inflammatory mediators fol...