Search results
- Title
- EFFECT OF CADMIUM AND SEASONALITY ON CRITICAL TEMPERATURES OF AEROBIC METABOLISM IN EASTERN OYSTERS, Crassostrea virginica Gmelin 1791
- Author
- Bagwe, Rita
- Date Created
- 2012
- Subjects--Topical
- Biology
- Description
- Cadmium (Cd) and elevated temperatures are common stressors in estuarine and coastal environments affecting intertidal mollusks such as oysters. Cd and elevated temperature can raise the metabolic demands of oysters due to the increase cost of det...
- Title
- RANK-L expression in Staphylococcus aureus- induced osteomyelitis, therapeutic intervention using nanotechnology and use of UV-killed bacteria as an osteoconductive coating for biomaterials.
- Author
- Somayaji, Shankari
- Date Created
- 2009
- Subjects--Topical
- Microbiology
- Description
-
Staphylococcus aureus is responsible for approximately 80% of all cases of human osteomyelitis. RANK-L is an essential signal produced by osteoblasts and is required for full osteoclastic differentiation. PGE2 - induced bone resorption involves bo...
- Title
- RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
- Author
- Daneshvar, Kaveh
- Date Created
- 2012
- Subjects--Topical
- Molecular biology, Biology, Genetics
- Description
- Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...
- Title
- Disulfide-trapped CXCL12-CXCL4 Chemokine Heterodimers Prevent Breast Cancer Progression
- Author
- Nguyen, Khanh
- Date Created
- 2021
- Subjects--Topical
- Biology
- Description
- Triple negative breast cancers (TNBCs), i.e., 10-15% of diagnosed breast cancers, have a triple negative (Her/2-, ER- and PR-) phenotype and are the most aggressive subtype of breast cancer. TNBCs have a worst prognosis because of the high probabi...
- Title
- Production of Immunomodulatory Proteins in Glycine max for use in Diagnostics and as Therapeutics
- Author
- Powell, Rebecca
- Date Created
- 2010
- Subjects--Topical
- Molecular biology
- Description
- ABSTRACTREBECCA DIANE POWELL. Production of Immunomodulatory Proteins in Glycine max for Use in Diagnostics and as Therapeutics. (Under the direction of DR. KENNETH L. BOST) Immunomodulatory proteins can be utilized in diagnostic assays, as tolera...
- Title
- Periostin and TGFBI in Breast Cancer Progression
- Author
- Phelps, Michelle
- Date Created
- 2015
- Subjects--Topical
- Biology, Cytology
- Description
- Dynamic interactions between cancer cells, supportive stromal cells, the extracellular matrix (ECM), and the immune system are critical to breast cancer progression. Periostin is an ECM protein correlated to poor outcomes in breast cancer. Periost...
- Title
- Polymer Mediated Delivery of Oligonucleotide and Trans Genes Toward More Efficient and Specific Therapies for Dystrophinopathies and Dystroglycanopathies
- Author
- Tucker, Jason
- Date Created
- 2014
- Subjects--Topical
- Molecular biology, Biology, Neurosciences
- Description
- Muscular dystrophies are genetic disorders caused by mutations in more than 30 genes, with no cure or effective treatment. Duchenne muscular dystrophy (DMD) is caused by frame-shift mutations in the dystrophin gene with little or no functional dys...
- Title
- Pleiotropic effects on the transcriptome and genome of transgenic soybeans resulting from transgene integration and expression in seed tissue
- Author
- Lambirth, Kevin
- Date Created
- 2015
- Subjects--Topical
- Molecular biology, Biology, Bioinformatics
- Description
- The seeds of the common soybean (Glycine max) produce and store large amounts of protein, making them an appealing bioreactor for producing valuable recombinant proteins at high levels. However, the effects of accumulating recombinant protein at h...
- Title
- ROLE OF AQUAPORINS DURING HEPATOCELLULAR CARCINOMA INITIATION AND PROGRESSION
- Author
- Mattocks, Matthew
- Date Created
- 2010
- Subjects--Topical
- Molecular biology, Cytology, Oncology
- Description
- Aquaporins (AQPs) are ubiquitously expressed proteinaceous water channels involved in numerous physiological processes including bile production and apoptosis. Aquaporins 8 and 9 are expressed in hepatocytes, and are down regulated in a rat model ...
- Title
- ROLE OF THE NOVEL DNA SENSORS cGAS, IFI16, AND ZBP1, DURING VIRAL INFECTIONS IN GLIA
- Author
- Jeffries, Austin
- Date Created
- 2020
- Subjects--Topical
- Immunology, Virology, Neurosciences
- Description
- Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
- Title
- Notch Serves as a Molecular Brake on Myogenesis, Protein Synthesis, and Growth in Skeletal Muscle
- Author
- Huot, Joshua
- Date Created
- 2018
- Subjects--Topical
- Molecular biology, Kinesiology
- Description
- Aging can be accompanied by aggressive loss of muscle mass (sarcopenia) and is a primary prognosticator for the reduced capacity of the elderly to accomplish basic activities of daily living. Several mechanisms within skeletal muscle lead to devel...
- Title
- Dissecting The Salivary Gland: Epithelial-Centered Dysfunction in Primary Sjögren’s Syndrome
- Author
- Noll, Braxton
- Date Created
- 2022
- Subjects--Topical
- Molecular biology
- Description
- Primary Sjögren’s syndrome (pSS) is an autoimmune disease of exocrine tissues causing dry mouth and eyes, mainly affecting women. A culmination of etiologic events leads to the loss of epithelial homeostasis resulting in the MMP9-mediated destruct...
- Title
- The Local Dynamics of Basement Membrane Breaching During Cancer Cell Invasion
- Author
- Nazari, Shayan
- Date Created
- 2022
- Subjects--Topical
- Biology
- Description
- Solid tumor metastasis is the leading cause of cancer-related mortality. Cancer invasion through the confining basement membrane (BM) is the initial step in tumor dissemination and metastasis, and it represents a key diagnostic feature of cancer. ...
- Title
- Diagnostic Ultrasound Assessment of Femoral Cartilage Health in Individuals with Patellofemoral Pain
- Author
- Jeon, Hyunjae
- Date Created
- 2021
- Subjects--Topical
- Kinesiology
- Description
- Patients with patellofemoral pain (PFP) experience pain during or after physical activities. Recent evidence suggests PFP is not only a painful symptom which hinders daily activity but also a potential marker for future development of patellofemor...
- Title
- Comparative analysis of Nitrosococcus genomes; isolation, physiological and genomic characterization of the new ammonia-oxidizing species Nitrosococcus wardiae, strain D1FHST; and molecular studies towards a better understanding of ammonia-dependent chemolithotrophy
- Author
- Wang, Lin
- Date Created
- 2016
- Subjects--Topical
- Molecular biology, Biology, Genetics
- Description
- Obligate aerobic chemolithoautotrophic ammonia-oxidzing bacteria (AOB) derive energy and reductant needed for growth solely from the oxidation of ammonia to nitrite thereby facilitating the process of nitritation. A strain of an ammonia-oxidizing ...
- Title
- BIOFLAVONOIDS GENISTEIN AND QUERCETIN TRIGGER ALTERNATIVE END JOINING PATHWAY OF DNA REPAIR
- Author
- GHOSH, ANINDITA
- Date Created
- 2019
- Subjects--Topical
- Biology
- Description
- Faithful repair of chromosomal double-strand breaks (DSBs) is crucial to genome stability and normal cell survival and proliferation. During normal metabolic processes and especially following exposure to DNA damaging agents including irradiation,...
- Title
- Apoptotic T-cell derived microparticles containing sonic hedgehog modulate endothelial cell functions in inflammation via rho kinase pathway
- Author
- Attal, Neha
- Date Created
- 2019
- Subjects--Topical
- Biology
- Description
- Impaired vascular regulation as a result of endothelial dysfunction is a major determinant of sepsis-associated liver failure. We have previously shown that inhibition of one signaling molecule rho-kinase (ROCK) predominantly restores endothelial ...
- Title
- EFFECTS OF SILIBININ ON ETHANOL-MEDIATED HEPATOCELLULAR CARCINOMA PROGRESSION IN MALE AND FEMALE MICE
- Author
- Warner, Elizabeth
- Date Created
- 2011
- Subjects--Topical
- Biology
- Description
- Ethanol is a significant risk for the development of hepatic cirrhosis and progression to hepatocellular carcinoma (HCC). While females are more susceptible to the deleterious effects of ethanol, the incidence of cirrhosis and HCC is significantly...
- Title
- IDENTIFICATION OF EPITHELIAL OVARIAN TUMOR SPECIFIC APTAMERS THAT BIND AND INTERNALIZE INTO TARGET CELLS
- Author
- Benedetto, Gregory
- Date Created
- 2015
- Subjects--Topical
- Chemistry, Biology
- Description
- New clinical tools that aid in the early diagnosis of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of the work presented here was to identify ovarian tumor specific singl...
- Title
- Hepatic Stellate Cell Transdifferentiation: Pro-fibrogenic Effectors
- Author
- Lakner, Ashley
- Date Created
- 2011
- Subjects--Topical
- Molecular biology, Biology
- Description
- Hepatic fibrosis is a significant cause of morbidity and mortality worldwide and can be described as exacerbated wound-healing marked by excessive deposition of extracellular matrix components, predominantly type I collagen. Chronic injury stimula...