Search results
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Title
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A STRUCTURAL AND FUNCTIONAL ANALYSIS OF NEMATOSTELLA VECTENSIS MAJOR INTRINSIC PROTEINS
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Author
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Taylor, Jonathon
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Date Created
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2020
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Subjects--Topical
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Biology, Cytology, Evolutionary developmental biology
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Description
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There is currently a major gap in understanding the physiological processes of tissue grade animals from early diverging phyla, particularly within the context of the molecular mechanisms in response to osmotic variation. A key protein family esse...
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Title
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ANCESTRAL COMPLEXITY AND LINEAGE SPECIFIC EXPANSIONS OF THE ANIMAL BZIP INTERACTOME
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Author
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Kane, Eric
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Date Created
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2017
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Subjects--Topical
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Bioinformatics, Evolutionary developmental biology
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Description
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Protein-protein interactions are central to the regulation and function of transcription factors in time- and cell-specific regulation of the genome. Increases in interactome complexity may serve as a mechanistic driver for evolutionary novelty. T...
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Title
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Characterizing a New Regulator of the ATR Signaling Pathway
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Author
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Biller, Megan
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Date Created
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2022
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Subjects--Topical
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Molecular biology, Biology
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Description
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Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...
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Title
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Dissecting functional differences in Hsp70 isoforms in nematostella vectensis
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Author
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Waller, Shawn
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Date Created
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2018
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Subjects--Topical
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Molecular biology
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Description
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Heat shock protein 70s (Hsp70s) are a highly conserved class of molecular chaperones that are involved in cellular processes in all organisms such as stress response, homeostatic maintenance, and cell cycle progression. The organism Nematostella v...
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Title
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EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
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Author
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Seegers, Sara
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Date Created
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2019
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Subjects--Topical
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Molecular biology, Virology, Biology
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Description
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Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...
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Title
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Exploring the Immune System using Hybrid Cube Nanoparticles
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Author
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McMillan, Jessica
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Date Created
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2021
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Subjects--Topical
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Biochemistry, Nanotechnology, Biology
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Description
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Nano-sized cubes made from nucleic acid material (NANPs) are ideal scaffolds for therapeutic nucleic acids (TNAs). Both utilize sequence specificity through base-pairing, providing controlled strand interaction, stability, and targeted targeting d...
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Title
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Fibroblast-driven Fibrosis and Inflammation in Breast Cancer Progression
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Author
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Samuels, Courtney
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Date Created
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2022
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Subjects--Topical
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Biology
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Description
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Breast cancer progression is promoted by both local inflammation and fibrosis. Indeed,accumulation of fibrous collagen is an independent prognosis marker of breast cancer. However, the mechanisms underlying the interplay between fibroblasts, infla...
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Title
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MACROPHAGES EXPRESSING NEUROPILIN-1 AND BREAST TUMOR PROGRESSION
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Author
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Helms, Rachel
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Date Created
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2015
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Subjects--Topical
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Biology
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Description
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Human breast carcinoma is the most commonly diagnosed cancer in women in the United States with patient mortality primarily resulting from metastasis of breast cancer cells to distant organs. Immune cells, including macrophages, are involved in ca...
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Title
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Oral Microbiome Signature for Hematological Cancer
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Author
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Langdon, Holden
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Date Created
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2020
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Subjects--Topical
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Biology
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Description
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BackgroundThe endogenous microbiome of healthy individuals in the oral cavity is diverse, representing over 700 different bacterial species. Some of these species may become opportunistic if certain elements in the microenvironment and host-respon...
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Title
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REGULATION OF APE1 BY NEIL3 ZINC FINGER-GRF REPEAT ON SINGLE-STRANDED DNA
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Author
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Ha, Anh
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Date Created
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2020
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Subjects--Topical
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Molecular biology, Cytology
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Description
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Base excision repair (BER) is a critical pathway in repairing single base lesions caused by oxidation, deamination, and alkylation. NEIL3 is a DNA glycosylase which functions in initiating BER pathway by recognizing and removing damaged bases. Alt...