Search results
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Title
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EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
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Author
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Seegers, Sara
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Date Created
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2019
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Subjects--Topical
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Molecular biology, Virology, Biology
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Description
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Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...
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Title
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RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
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Author
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Daneshvar, Kaveh
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Date Created
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2012
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Subjects--Topical
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Molecular biology, Biology, Genetics
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Description
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Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...
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Title
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Periostin and TGFBI in Breast Cancer Progression
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Author
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Phelps, Michelle
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Date Created
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2015
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Subjects--Topical
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Biology, Cytology
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Description
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Dynamic interactions between cancer cells, supportive stromal cells, the extracellular matrix (ECM), and the immune system are critical to breast cancer progression. Periostin is an ECM protein correlated to poor outcomes in breast cancer. Periost...
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Title
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ROLE OF AQUAPORINS DURING HEPATOCELLULAR CARCINOMA INITIATION AND PROGRESSION
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Author
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Mattocks, Matthew
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Date Created
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2010
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Subjects--Topical
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Molecular biology, Cytology, Oncology
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Description
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Aquaporins (AQPs) are ubiquitously expressed proteinaceous water channels involved in numerous physiological processes including bile production and apoptosis. Aquaporins 8 and 9 are expressed in hepatocytes, and are down regulated in a rat model ...
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Title
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ROLE OF THE NOVEL DNA SENSORS cGAS, IFI16, AND ZBP1, DURING VIRAL INFECTIONS IN GLIA
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Author
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Jeffries, Austin
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Date Created
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2020
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Subjects--Topical
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Immunology, Virology, Neurosciences
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Description
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Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
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Title
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REGULATION OF APE1 BY NEIL3 ZINC FINGER-GRF REPEAT ON SINGLE-STRANDED DNA
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Author
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Ha, Anh
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Date Created
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2020
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Subjects--Topical
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Molecular biology, Cytology
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Description
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Base excision repair (BER) is a critical pathway in repairing single base lesions caused by oxidation, deamination, and alkylation. NEIL3 is a DNA glycosylase which functions in initiating BER pathway by recognizing and removing damaged bases. Alt...
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Title
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Dissecting functional differences in Hsp70 isoforms in nematostella vectensis
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Author
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Waller, Shawn
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Date Created
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2018
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Subjects--Topical
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Molecular biology
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Description
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Heat shock protein 70s (Hsp70s) are a highly conserved class of molecular chaperones that are involved in cellular processes in all organisms such as stress response, homeostatic maintenance, and cell cycle progression. The organism Nematostella v...
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Title
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The Local Dynamics of Basement Membrane Breaching During Cancer Cell Invasion
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Author
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Nazari, Shayan
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Date Created
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2022
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Subjects--Topical
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Biology
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Description
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Solid tumor metastasis is the leading cause of cancer-related mortality. Cancer invasion through the confining basement membrane (BM) is the initial step in tumor dissemination and metastasis, and it represents a key diagnostic feature of cancer. ...