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Low-dose metformin as a monotherapy does not reduce non-small-cell lung cancer tumor burden in mice
Title
Low-dose metformin as a monotherapy does not reduce non-small-cell lung cancer tumor burden in mice
Author
Marino, Joseph S., Stott Bond, Nicole L., Dréau, Didier, Marriott, Ian, Bennett, Jeanette M., Turner, Michael J., Arthur, Susan
Subjects--Topical
Lungs--Cancer, Musculoskeletal system
Description
Non-small-cell lung cancer (NSCLC) makes up 80–85% of lung cancer diagnoses. Lung cancer patients undergo surgical procedures, chemotherapy, and/or radiation. Chemotherapy and radiation can induce deleterious systemic side effects, particularly wi...
Low-dose metformin treatment reduces in vitro growth of the LL/2 non-small cell lung cancer cell line
Title
Low-dose metformin treatment reduces in vitro growth of the LL/2 non-small cell lung cancer cell line
Author
Marino, Joseph S., Dreau, Didier, Marriott, Ian, Bennett, Jeanette M.
Date Created
2022
Subjects--Topical
Cancer cells, Lungs--Cancer
Description
Lung cancer maintains a relatively small survival rate (~19%) over a 5-year period and up to 80-85% of all lung cancer diagnoses are Non-Small Cell Lung Cancer (NSCLC). To determine whether metformin reduces non-small cell lung cancer (NSCLC) LL/2...
Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Title
Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Author
Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created
2020
Subjects--Topical
Nucleic acids, Chemistry
Description
Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Title
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author
Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created
2020
Subjects--Topical
Nucleic acids, Chemistry
Description
Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Title
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Author
Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
Date Created
2023
Subjects--Topical
Nucleic acids, Chemistry
Description
The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...