Search results
-
-
Title
-
Notch inhibition via GSI treatment elevates protein synthesis in C2C12 myotubes
-
Author
-
Arthur, Susan, Huot, Joshua, Marino, Joseph S., Turner, Michael
-
Subjects--Topical
-
Proteins--Synthesis, Muscle proteins
-
Description
-
The role of Notch signaling is widely studied in skeletal muscle regeneration but little is known about its influences on muscle protein synthesis (MPS). The purpose of this study was to investigate whether Notch signaling is involved in the regul...
-
-
Title
-
GSI treatment preserves protein synthesis in C2C12 myotubes
-
Author
-
Arthur, Susan, Huot, Joshua, Marino, Joseph S., Thompson, Brian, McMullen, Charlotte
-
Subjects--Topical
-
Muscle proteins, Cells
-
Description
-
It has been demonstrated that inhibiting Notch signaling through γ-secretase inhibitor (GSI) treatment increases myogenesis, AKT/mTOR signaling, and muscle protein synthesis (MPS) in C2C12 myotubes. The purpose of this study was to determine if GS...
