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ELUCIDATING THE EFFECTS OF MUTATION AND EVOLUTIONARY DIVERGENCE UPON PROTEIN STRUCTURE QUANTITATIVE STABILITY/FLEXIBILITY RELATIONSHIPS
Title
ELUCIDATING THE EFFECTS OF MUTATION AND EVOLUTIONARY DIVERGENCE UPON PROTEIN STRUCTURE QUANTITATIVE STABILITY/FLEXIBILITY RELATIONSHIPS
Author
Verma, Deeptak
Date Created
2012
Subjects--Topical
Bioinformatics
Description
The importance of flexibility and stability on protein function has been recognized for over five decades. A protein must be flexible enough to mediate a reaction pathway, yet rigid enough to achieve high fidelity in molecular recognition. To unde...
Functional Dynamics in Beta-Lactamase: Insights into Substrate Recognition and Inhibition
Title
Functional Dynamics in Beta-Lactamase: Insights into Substrate Recognition and Inhibition
Author
Avery, Christopher
Date Created
2023
Subjects--Topical
Bioinformatics, Biophysics, Physics
Description
Beta-lactamase proteins are among the most prominent causes of antibiotic resistance. These enzymes confer resistance to beta lactam antibiotics, which are commonly used to treat bacterial infections. In recent years, novel beta-lactamase have eme...