Search results
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Title
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GSI treatment preserves protein synthesis in C2C12 myotubes
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Author
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Arthur, Susan, Huot, Joshua, Marino, Joseph S., Thompson, Brian, McMullen, Charlotte
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Subjects--Topical
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Muscle proteins, Cells
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Description
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It has been demonstrated that inhibiting Notch signaling through γ-secretase inhibitor (GSI) treatment increases myogenesis, AKT/mTOR signaling, and muscle protein synthesis (MPS) in C2C12 myotubes. The purpose of this study was to determine if GS...
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Title
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High fat rodent models of type 2 diabetes : from rodent to human
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Author
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Stott Bond, Nicole L., Marino, Joseph S.
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Subjects--Topical
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Non-insulin-dependent diabetes, Metabolism
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Description
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Poor dietary habits contribute to increased incidences of obesity and related co-morbidities, such as type 2 diabetes (T2D). The biological, genetic, and pathological implications of T2D, are commonly investigated using animal models induced by a ...
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Title
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Low-dose metformin as a monotherapy does not reduce non-small-cell lung cancer tumor burden in mice
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Author
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Marino, Joseph S., Stott Bond, Nicole L., Dréau, Didier, Marriott, Ian, Bennett, Jeanette M., Turner, Michael J., Arthur, Susan
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Subjects--Topical
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Lungs--Cancer, Musculoskeletal system
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Description
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Non-small-cell lung cancer (NSCLC) makes up 80–85% of lung cancer diagnoses. Lung cancer patients undergo surgical procedures, chemotherapy, and/or radiation. Chemotherapy and radiation can induce deleterious systemic side effects, particularly wi...
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Title
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Low-dose metformin treatment reduces in vitro growth of the LL/2 non-small cell lung cancer cell line
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Author
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Marino, Joseph S., Dreau, Didier, Marriott, Ian, Bennett, Jeanette M.
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Date Created
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2022
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Subjects--Topical
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Cancer cells, Lungs--Cancer
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Description
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Lung cancer maintains a relatively small survival rate (~19%) over a 5-year period and up to 80-85% of all lung cancer diagnoses are Non-Small Cell Lung Cancer (NSCLC). To determine whether metformin reduces non-small cell lung cancer (NSCLC) LL/2...
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Title
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Notch inhibition via GSI treatment elevates protein synthesis in C2C12 myotubes
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Author
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Arthur, Susan, Huot, Joshua, Marino, Joseph S., Turner, Michael
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Subjects--Topical
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Proteins--Synthesis, Muscle proteins
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Description
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The role of Notch signaling is widely studied in skeletal muscle regeneration but little is known about its influences on muscle protein synthesis (MPS). The purpose of this study was to investigate whether Notch signaling is involved in the regul...
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Title
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The association of COPD exacerbations with new onset type 2 diabetes among Medicare patients
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Author
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Marino, Joseph S., Ruban, Cynthiya, Saunders, Bill, Blanchette, Christopher M.
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Subjects--Topical
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Lungs--Diseases, Obstructive, Non-insulin-dependent diabetes
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Description
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Objective: Chronic obstructive pulmonary disease (COPD) is highly prevalent in the elderly population and typically reduces overall quality of life. Exacerbations of COPD are commonly treated with corticosteroids, a class of drug known to cause in...