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- Afonin, Kirill A. (x)
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- Title
- Artificial immune cell, AI-cell, a new tool to predict interferon production by peripheral blood monocytes in response to nucleic acid nanoparticles
- Author
- Afonin, Kirill A., Chandler, Morgan, Halman, Justin
- Date Created
- 2022
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human immune system, can offer innovative therapeutic strategies to overcome the limitations of traditional nucleic acid therapies. Each set of NANPs is unique in th...
- Title
- Biomotors, viral assembly, and rna nanobiotechnology: current achievements and future directions
- Author
- Afonin, Kirill A., Rolband, Lewis
- Date Created
- 2022
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent adv...
- Title
- Broccoli fluorets : split aptamers as a user-friendly fluorescent toolkit for dynamic RNA nanotechnology
- Author
- Afonin, Kirill A., Chandler, Morgan, Halman, Justin
- Date Created
- 2018
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- RNA aptamers selected to bind fluorophores and activate their fluorescence offer a simple and modular way to visualize native RNAs in cells. Split aptamers which are inactive until the halves are brought within close proximity can become useful fo...
- Title
- Change in lipofectamine carrier as a tool to fine-tune immunostimulation of nucleic acid nanoparticles
- Author
- Afonin, Kirill A., Newton, Hannah S., Xu, Jie
- Date Created
- 2023
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Nucleic acid nanoparticles (NANPs) require a carrier to allow for their intracellular delivery to immune cells. Cytokine production, specifically type I and III interferons, allows for reliable monitoring of the carrier effect on NANP immunostimul...
- Title
- Characterization of cationic bolaamphiphile vesicles for sirna delivery into tumors and brain
- Author
- Afonin, Kirill A., Kim, Taejin, Gupta, Kshitij
- Date Created
- 2020
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Small interfering RNAs (siRNAs) are potential therapeutic substances due to their gene silencing capability as exemplified by the recent approval by the US Food and Drug Administration (FDA) of the first siRNA therapeutic agent (patisiran). Howeve...
- Title
- DNA-templated fluorescent silver nanoclusters inhibit bacterial growth while being non-toxic to mammalian cells
- Author
- Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
- Date Created
- 2021
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Silver has a long history of antibacterial effectiveness. The combination of atomically precise metal nanoclusters with the field of nucleic acid nanotechnology has given rise to DNA-templated silver nanoclusters (DNA-AgNCs) which can be engineere...
- Title
- Exosome mediated delivery of functional nucleic acid nanoparticles (NANPs)
- Author
- Afonin, Kirill A., Ke, Weina
- Date Created
- 2020
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- RNAi-based technologies have shown biomedical potential; however, safe and efficient delivery of RNA remains a barrier for their broader clinical applications. Nucleic acid nanoparticles (NANPs) programmed to self-assemble and organize multiple th...
- Title
- Expanding structural space for immunomodulatory nucleic acid nanoparticles (NANPs) via spatial arrangement of their therapeutic moieties
- Author
- Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
- Date Created
- 2022
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Different therapeutic nucleic acids (TNAs) can be unified in a single structure by their elongation with short oligonucleotides designed to self-assemble into nucleic acid nanoparticles (NANPs). With this approach, therapeutic cocktails with preci...
- Title
- Functionally-interdependent shape-switching nanoparticles with controllable properties
- Author
- Afonin, Kirill A., Halman, Justin, Chandler, Morgan
- Date Created
- 2017
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
- Title
- The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
- Author
- Afonin, Kirill A., Marriott, Ian, Halman, Justin
- Date Created
- 2020
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
- Title
- Induction of cytokines by nucleic acid nanoparticles (NANPs) depends on the type of delivery carrier
- Author
- Afonin, Kirill A., Chandler, Morgan, Avila, Yelixza I.
- Date Created
- 2021
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these ...
- Title
- Special issue nanotechnology to overcome the world's most critical health issues: liposomes and beyond-a themed issue dedicated to Professor Yechezkel Barenholz
- Author
- Afonin, Kirill A., Dobrovolskaia, Marina
- Date Created
- 2023
- Subjects--Topical
- Nucleic acids, Chemistry
- Title
- The recognition of and reactions to nucleic acid nanoparticles by human immune cells
- Author
- Afonin, Kirill A., Bila, Dominika, Panigaj, Martin
- Date Created
- 2021
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- The relatively straightforward methods of designing and assembling various functional nucleic acids into nanoparticles offer advantages for applications in diverse diagnostic and therapeutic approaches. However, due to the novelty of this approach...
- Title
- Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
- Author
- Afonin, Kirill A., Marriott, Ian, Halman, Justin
- Date Created
- 2020
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...
- Title
- Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
- Author
- Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
- Date Created
- 2023
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...
- Title
- Structure and composition define immunorecognition of nucleic acid nanoparticles
- Author
- Afonin, Kirill A.
- Date Created
- 2022, 2022, 2022
- Subjects--Topical
- Immune system, Interferon, Nucleic acids
- Title
- Break to build : isothermal assembly of nucleic acid nanoparticles (NANPs) via enzymatic degradation
- Author
- Beasock, Damian, Ha, Anh, Halman, Justin, Afonin, Kirill A.
- Date Created
- 2023
- Subjects--Topical
- Genetics, Peptides
- Description
- The intrinsic properties of RNA and DNA biopolymers emphasized by engineered nucleic acid nanoparticles (NANPs) offer accelerated development of next-generation therapies. The rational design of NANPs facilitates programmable architectures intende...
- Title
- Functionally-interdependent shape-switching nanoparticles with controllable properties
- Author
- Halman, Justin, Khisamutdinov, Emil F., Afonin, Kirill A., Satterwhite, Emily, Roark, Brandon, Chandler, Morgan, Ivanina, Anna, Viard, Mathias, Bindewald, Eckart, Kasprzak, Wojciech K., Panigaj, Martin, Bui, My N., Lu, Jacob S., Miller, Johann, Shapiro, Bruce A., Dobrovolskaia, Marina A.
- Subjects--Topical
- Nucleic acids, Nanotechnology
- Description
- We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
- Title
- The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
- Author
- Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
- Subjects--Topical
- Immunology, Nucleic acids, Nanoparticles
- Description
- Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
- Title
- Biomotors, viral assembly, and RNA nanobiotechnology : current achievements and future directions
- Author
- Robland, Lewis, Beasock, Damian, Afonin, Kirill A., Schlick, Tamar
- Date Created
- 2022
- Subjects--Topical
- Viruses, Nanotechnology
- Description
- The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent adv...