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Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications
Title
Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications
Author
Truman, Andrew, Zheng, Bo, Omkar, Siddhi, Takakuwa, Jade E.
Date Created
2022
Subjects--Topical
Proteins, Molecular biology
Description
Hsp70 interactions are critical for cellular viability and the response to stress. Previous attempts to characterize Hsp70 interactions have been limited by their transient nature and the inability of current technologies to distinguish direct ver...
Current perspectives of telomerase structure and function in eukaryotes with emerging views on telomerase in human parasites
Title
Current perspectives of telomerase structure and function in eukaryotes with emerging views on telomerase in human parasites
Author
Chakrabarti, Kausik, Dey, Abhishek
Date Created
2018
Subjects--Topical
Molecular biology, Evolution (Biology)
Description
Replicative capacity of a cell is strongly correlated with telomere length regulation. Aberrant lengthening or reduction in the length of telomeres can lead to health anomalies, such as cancer or premature aging. Telomerase is a master regulator f...
Molecular function recognition by supervised projection pursuit machine learning
Title
Molecular function recognition by supervised projection pursuit machine learning
Author
Jacobs, Donald J., Grear, Tyler, Avery, Chris, Patterson, John
Date Created
2021
Subjects--Topical
Molecular biology, Pharmaceutical chemistry
Description
Identifying mechanisms that control molecular function is a significant challenge in pharmaceutical science and molecular engineering. Here, we present a novel projection pursuit recurrent neural network to identify functional mechanisms in the co...