Search results
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Title
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Cytosolic DNA sensors and CNS responses to viral pathogens
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Author
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Marriott, Ian, Jeffries, Austin
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Subjects--Topical
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DNA, Virus diseases
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Description
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Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
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Title
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Cytosolic DNA sensors and glial responses to endogenous DNA
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Author
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Marriott, Ian, Suptela, Alexander J.
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Date Created
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2023
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Subjects--Topical
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Genomics, DNA
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Description
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Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic integrity ...
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Title
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Low-dose metformin as a monotherapy does not reduce non-small-cell lung cancer tumor burden in mice
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Author
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Marino, Joseph S., Stott Bond, Nicole L., Dréau, Didier, Marriott, Ian, Bennett, Jeanette M., Turner, Michael J., Arthur, Susan
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Subjects--Topical
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Lungs--Cancer, Musculoskeletal system
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Description
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Non-small-cell lung cancer (NSCLC) makes up 80–85% of lung cancer diagnoses. Lung cancer patients undergo surgical procedures, chemotherapy, and/or radiation. Chemotherapy and radiation can induce deleterious systemic side effects, particularly wi...
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Title
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Low-dose metformin treatment reduces in vitro growth of the LL/2 non-small cell lung cancer cell line
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Author
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Marino, Joseph S., Dreau, Didier, Marriott, Ian, Bennett, Jeanette M.
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Date Created
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2022
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Subjects--Topical
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Cancer cells, Lungs--Cancer
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Description
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Lung cancer maintains a relatively small survival rate (~19%) over a 5-year period and up to 80-85% of all lung cancer diagnoses are Non-Small Cell Lung Cancer (NSCLC). To determine whether metformin reduces non-small cell lung cancer (NSCLC) LL/2...
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Title
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Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
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Author
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Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
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Date Created
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2023
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...
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Title
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Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles (NANPs)
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Author
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Panigaj, Martin, Skelly, Elizabeth, Beasock, Damian, Marriott, Ian
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Date Created
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2023
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Subjects--Topical
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Immunology, Immune response--Regulation
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Description
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The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...
