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ELUCIDATING THE EFFECTS OF MUTATION AND EVOLUTIONARY DIVERGENCE UPON PROTEIN STRUCTURE QUANTITATIVE STABILITY/FLEXIBILITY RELATIONSHIPS
Title
ELUCIDATING THE EFFECTS OF MUTATION AND EVOLUTIONARY DIVERGENCE UPON PROTEIN STRUCTURE QUANTITATIVE STABILITY/FLEXIBILITY RELATIONSHIPS
Author
Verma, Deeptak
Date Created
2012
Subjects--Topical
Bioinformatics
Description
The importance of flexibility and stability on protein function has been recognized for over five decades. A protein must be flexible enough to mediate a reaction pathway, yet rigid enough to achieve high fidelity in molecular recognition. To unde...
Microbial Mutations - Accumulation in Microfluidics and Collateral Sensitivity
Title
Microbial Mutations - Accumulation in Microfluidics and Collateral Sensitivity
Author
Turner, Nathan
Date Created
2023
Subjects--Topical
Bioinformatics
Description
Mutations are a primary source of genetic variation and a major driving force in evolution by influencing survivability (fitness), genetic disease, and the development of complex traits such as antibiotic resistance. However, studying the mutation...