Search results
-
-
Title
-
Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
-
Author
-
Grdzelishvili, Valery, Goad, Dakota, Bressy, Christian, Holbrook, Molly
-
Subjects--Topical
-
Vesicular stomatitis, Cancer, Viruses
-
Description
-
Vesicular stomatitis virus (VSV) is a promising oncolytic virus (OV) against different malignancies, including pancreatic ductal adenocarcinoma (PDAC). Our previous studies have demonstrated that VSV-based OVs are effective against the majority of...
-
-
Title
-
Cell cycle arrest in G2/M phase enhances replication of interferon-sensitive cytoplasmic RNA viruses via inhibition of antiviral gene expression
-
Author
-
Grdzelishvili, Valery, Bressy, Christian, Droby, Gaith N., Maldonado, Bryant D., Steuerwald, Nury
-
Subjects--Topical
-
Cancer, Viruses
-
Description
-
Vesicular stomatitis virus (VSV) (a rhabdovirus) and its variant VSV-ΔM51 are widely used model systems to study mechanisms of virus-host interactions. Here, we investigated how the cell cycle affects replication of these viruses using an array of...
-
-
Title
-
Combining oncolytic virotherapy with p53 tumor suppressor gene therapy
-
Author
-
Grdzelishvili, Valery, Bressy, Christian, Hastie, Eric Lawrence
-
Subjects--Topical
-
Cancer, Gene therapy
-
Description
-
Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. With the first U.S. Food and Drug Administration-approved OV, dozens of clinical trials ongoing, and an abundance of tr...
-
-
Title
-
Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
-
Author
-
Grdzelishvili, Valery, Hastie, Eric Lawrence, Cataldi, Marcela, Moerdyk-Schauwecker, Megan J., Felt, Sebastien A., Steuerwald, Nury
-
Subjects--Topical
-
Cancer, Viruses
-
Description
-
Vesicular stomatitis virus (VSV) based recombinant viruses (such as VSV-ΔM51) are effective oncolytic viruses (OVs) against a majority of pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to VSV...