Protein synthesis and muscle stem cells are crucial components of adequate muscle repair in healthy individuals that are dysregulated in a variety of diseases states. A key regulator of muscle stem cell activation and coordination of downstream mu...
Skeletal muscle is a primary regulator of glucose homeostasis, accounting for the majority of post-prandial glucose disposal. However states of skeletal muscle insulin-resistance result in severely attenuated glucose uptake and consequently hyperg...
Aging can be accompanied by aggressive loss of muscle mass (sarcopenia) and is a primary prognosticator for the reduced capacity of the elderly to accomplish basic activities of daily living. Several mechanisms within skeletal muscle lead to devel...
Lung cancer is the second most common cancer and maintains a relatively small survival rate (~20%). Non-Small Cell Lung Cancer (NSCLC) makes up 80-85% of all lung cancer diagnoses. Lung cancer patients routinely undergo surgical procedures, chemot...
Chronic saturated fatty acid exposure causes skeletal muscle cells to develop insulin resistance, which contributes to the pathogenesis of type 2 diabetes mellitus. Recently, microRNAs have been viewed as novel molecules that contribute to the reg...