Search results | J. Murrey Atkins Library

Title: Break to build : isothermal assembly of nucleic acid nanoparticles (NANPs) via enzymatic degradation
Author: Beasock, Damian, Ha, Anh, Halman, Justin, Afonin, Kirill A.
Date Created: 2023
Subjects--Topical: Genetics, Peptides
Description: The intrinsic properties of RNA and DNA biopolymers emphasized by engineered nucleic acid nanoparticles (NANPs) offer accelerated development of next-generation therapies. The rational design of NANPs facilitates programmable architectures intende...

Title: Editorial for the special issue on nucleic acid architectures for therapeutics, diagnostics, devices and materials
Author: Afonin, Kirill A., Halman, Justin
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry

Title: Immunostimulatory Properties of Nucleic Acid Nanoparticles
Author: Halman, Justin
Date Created: 2020
Subjects--Topical: Nanoscience
Description: Nucleic acids (DNA and RNA) are ubiquitous biomolecules found throughout all living organisms. They can act as genetic information storage and messengers, enzymes, molecular switches, and much more. Although DNA is used almost exclusively for its ...

Title: Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Author: Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...

Title: The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author: Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
Subjects--Topical: Immunology, Nucleic acids, Nanoparticles
Description: Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...

Title: The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author: Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...

Title: Toll-like receptor-mediated recognition of nucleic acid nanoparticles (NANPs) in human primary blood cells
Author: Afonin, Kirill A., Truong, Nguyen, Halman, Justin
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry
Description: Infusion reactions (IRs) create a translational hurdle for many novel therapeutics, including those utilizing nanotechnology. Nucleic acid nanoparticles (NANPs) are a novel class of therapeutics prepared by rational design of relatively short olig...