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Break to build : isothermal assembly of nucleic acid nanoparticles (NANPs) via enzymatic degradation
Title
Break to build : isothermal assembly of nucleic acid nanoparticles (NANPs) via enzymatic degradation
Author
Beasock, Damian, Ha, Anh, Halman, Justin, Afonin, Kirill A.
Date Created
2023
Subjects--Topical
Genetics, Peptides
Description
The intrinsic properties of RNA and DNA biopolymers emphasized by engineered nucleic acid nanoparticles (NANPs) offer accelerated development of next-generation therapies. The rational design of NANPs facilitates programmable architectures intende...
Change in lipofectamine carrier as a tool to fine-tune immunostimulation of nucleic acid nanoparticles
Title
Change in lipofectamine carrier as a tool to fine-tune immunostimulation of nucleic acid nanoparticles
Author
Afonin, Kirill A., Newton, Hannah S., Xu, Jie
Date Created
2023
Subjects--Topical
Nucleic acids, Chemistry
Description
Nucleic acid nanoparticles (NANPs) require a carrier to allow for their intracellular delivery to immune cells. Cytokine production, specifically type I and III interferons, allows for reliable monitoring of the carrier effect on NANP immunostimul...
Demonstrating the synthesis and antibacterial properties of nanostructured silver
Title
Demonstrating the synthesis and antibacterial properties of nanostructured silver
Author
Rolband, Lewis, Godakhindi, Varsha, Vivero-Escoto, Juan L., Afonin, Kirill A.
Date Created
2023
Subjects--Topical
Antibacterial agents, Silver
Description
Investigating and understanding novel antibacterial agents is a necessary task as there is a constant increase in the number of multidrug-resistant bacterial species. The use of nanotechnology to combat drug-resistant bacteria is an important rese...
Special issue nanotechnology to overcome the world's most critical health issues: liposomes and beyond-a themed issue dedicated to Professor Yechezkel Barenholz
Title
Special issue nanotechnology to overcome the world's most critical health issues: liposomes and beyond-a themed issue dedicated to Professor Yechezkel Barenholz
Author
Afonin, Kirill A., Dobrovolskaia, Marina
Date Created
2023
Subjects--Topical
Nucleic acids, Chemistry
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Title
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Author
Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
Date Created
2023
Subjects--Topical
Nucleic acids, Chemistry
Description
The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...